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ampH peptidoglycan DD-carboxypeptidase/peptidoglycan DD-endopeptidase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946904, updated on 19-Sep-2024

Summary

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Official Symbol
ampH
Official Full Name
peptidoglycan DD-carboxypeptidase/peptidoglycan DD-endopeptidase
Primary source
ECOCYC:EG12867
Locus tag
b0376
See related
ASAP:ABE-0001292
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0371; yaiH
Summary
AmpH is a penicillin-binding protein with no known enzymatic function. [More information is available at EcoCyc: EG12867].
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Genomic context

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Sequence:
NC_000913.3 (395130..396287, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene IS3 element protein InsF Neighboring gene IS3 element protein InsE Neighboring gene putative DNA-binding transcriptional regulator IprA Neighboring gene peptide antibiotic/peptide nucleic acid transporter Neighboring gene surface-exposed outer membrane lipoprotein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. AmpH, a bifunctional DD-endopeptidase and DD-carboxypeptidase of Escherichia coli. González-Leiza SM, et al. J Bacteriol, 2011 Dec. PMID 22001512, Free PMC Article
  2. Comparison of high-performance liquid chromatography and fluorophore-assisted carbohydrate electrophoresis methods for analyzing peptidoglycan composition of Escherichia coli. Li SY, et al. Anal Biochem, 2004 Mar 1. PMID 14769329, Free PMC Article
  3. AmpC and AmpH, proteins related to the class C beta-lactamases, bind penicillin and contribute to the normal morphology of Escherichia coli. Henderson TA, et al. J Bacteriol, 1997 Oct. PMID 9324260, Free PMC Article
  4. Approaching the physiological functions of penicillin-binding proteins in Escherichia coli. Young KD. Biochimie, 2001 Jan. PMID 11254981
  5. Escherichia coli mutants lacking all possible combinations of eight penicillin binding proteins: viability, characteristics, and implications for peptidoglycan synthesis. Denome SA, et al. J Bacteriol, 1999 Jul. PMID 10383966, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables carboxypeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables penicillin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidoglycan catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell shape IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peptidoglycan DD-carboxypeptidase/peptidoglycan DD-endopeptidase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    395130..396287 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414910.1 peptidoglycan DD-carboxypeptidase/peptidoglycan DD-endopeptidase [Escherichia coli str. K-12 substr. MG1655]

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376FRN3
    Conserved Domains (1) summary
    PRK10662
    Location:1 → 378
    PRK10662; beta-lactam binding protein AmpH; Provisional
Nucleotide Protein
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