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yajO 1-deoxyxylulose-5-phosphate synthase YajO [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946903, updated on 1-May-2025
Official Symbol
yajO
Official Full Name
1-deoxyxylulose-5-phosphate synthase YajO
Primary source
ECOCYC:G6236
Locus tag
b0419
See related
ASAP:ABE-0001457
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0413
Summary
YajO converts 2-carboxybenzaldehyde, like other AKR7A family enzymes, however specificities toward other substrates was not demonstrated. [More information is available at EcoGene: EG13611]. Overexpression of YajO from a multicopy plasmid leads to resistance to the HMP (4-amino-2-methyl-5-hydroxymethylpyrimidine) analog bacimethrin. [More information is available at EcoCyc: G6236].
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Sequence:
NC_000913.3 (437161..438135, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene transcription antitermination protein NusB Neighboring gene thiamine monophosphate kinase Neighboring gene phosphatidylglycerophosphatase A Neighboring gene 1-deoxy-D-xylulose-5-phosphate synthase Neighboring gene geranyl diphosphate/farnesyl diphosphate synthase Neighboring gene exodeoxyribonuclease VII subunit XseB

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Cloning and nucleotide sequence of the ispA gene responsible for farnesyl diphosphate synthase activity in Escherichia coli. Fujisaki S, et al. J Biochem, 1990 Dec. PMID 2089044
  2. Isolation and preliminary characterization of Escherichia coli mutants deficient in exonuclease VII. Vales LD, et al. J Bacteriol, 1983 Sep. PMID 6350262, Free PMC Article
  3. Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coli. Kerner MJ, et al. Cell, 2005 Jul 29. PMID 16051146
  4. A genetic screen for the identification of thiamin metabolic genes. Lawhorn BG, et al. J Biol Chem, 2004 Oct 15. PMID 15292217
  5. Conversion of methylglyoxal to acetol by Escherichia coli aldo-keto reductases. Ko J, et al. J Bacteriol, 2005 Aug. PMID 16077126, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within isoprenoid biosynthetic process via mevalonate EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within thiamine metabolic process EXP
Inferred from Experiment
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
1-deoxyxylulose-5-phosphate synthase YajO

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    437161..438135 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414953.2 1-deoxyxylulose-5-phosphate synthase YajO [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414953.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6M9WYK3, A0AB74PMS7
    Conserved Domains (1) summary
    cd19079
    Location:2 → 312
    AKR_EcYajO-like; Escherichia coli YajO and similar proteins
Nucleotide Protein
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