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hemL glutamate-1-semialdehyde 2,1-aminomutase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946892, updated on 4-Feb-2026
Official Symbol
hemL
Official Full Name
glutamate-1-semialdehyde 2,1-aminomutase
Primary source
ECOCYC:EG10432
Locus tag
b0154
See related
ASAP:ABE-0000529
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0153; gsa; popC
Summary
Mg(2+) stimulon-PhoPQ regulon, EvgAS-PhoPQ cascade enhanced expression subset. [More information is available at EcoGene: EG10432]. Glutamate-1-semialdehyde aminotransferase catalyzes the pyridoxal 5'-phosphate-dependent reaction which converts GSA to delta-aminolevulinate (ALA). [More information is available at EcoCyc: EG10432].
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Sequence:
NC_000913.3 (173602..174882, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene Fe(3(+)) hydroxamate ABC transporter ATP binding subunit Neighboring gene Fe(3(+)) hydroxamate ABC transporter periplasmic binding protein Neighboring gene Fe(3(+)) hydroxamate ABC transporter membrane subunit Neighboring gene protein YadX Neighboring gene chloride:H(+) antiporter ClcA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The Escherichia coli hemL gene encodes glutamate 1-semialdehyde aminotransferase. Ilag LL, et al. J Bacteriol, 1991 Jun. PMID 2045363, Free PMC Article
  2. Structural genes of glutamate 1-semialdehyde aminotransferase for porphyrin synthesis in a cyanobacterium and Escherichia coli. Grimm B, et al. Mol Gen Genet, 1991 Jan. PMID 1900346
  3. Activity and spectroscopic properties of the Escherichia coli glutamate 1-semialdehyde aminotransferase and the putative active site mutant K265R. Ilag LL, et al. Biochemistry, 1992 Aug 11. PMID 1643048
  4. Complex formation between glutamyl-tRNA reductase and glutamate-1-semialdehyde 2,1-aminomutase in Escherichia coli during the initial reactions of porphyrin biosynthesis. Lüer C, et al. J Biol Chem, 2005 May 13. PMID 15757895
  5. Identification and molecular characterization of the Mg2+ stimulon of Escherichia coli. Minagawa S, et al. J Bacteriol, 2003 Jul. PMID 12813061, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of glutamyl-tRNA reductase and glutamate-1-semialdehyde 2,1-aminomutase complex formation in Escherichia coli during the initial reactions of porphyrin biosynthesis
    Title: Complex formation between glutamyl-tRNA reductase and glutamate-1-semialdehyde 2,1-aminomutase in Escherichia coli during the initial reactions of porphyrin biosynthesis.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glutamate-1-semialdehyde 2,1-aminomutase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamate-1-semialdehyde 2,1-aminomutase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutamate-1-semialdehyde 2,1-aminomutase activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in porphyrin-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protoporphyrinogen IX biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tetrapyrrole biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
Preferred Names
glutamate-1-semialdehyde 2,1-aminomutase
NP_414696.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    173602..174882 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414696.1 glutamate-1-semialdehyde 2,1-aminomutase

    See identical proteins and their annotated locations for NP_414696.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A828N6N7
    Conserved Domains (1) summary
    PRK00062
    Location:1 → 426
    PRK00062; glutamate-1-semialdehyde 2,1-aminomutase
Nucleotide Protein
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