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sbmA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946884, updated on 11-Sep-2024

Summary

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Official Symbol
sbmA
Primary source
ECOCYC:EG10928
Locus tag
b0377
See related
ASAP:ABE-0001297
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0372
Summary
The sbmA gene product has been shown through deletion, mutation and complementation studies to code for the specific inner-membrane transport protein for Microcin 25 (Mcc25). [More information is available at EcoCyc: EG10928].
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Genomic context

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Sequence:
NC_000913.3 (396639..397859)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative DNA-binding transcriptional regulator IprA Neighboring gene peptidoglycan DD-carboxypeptidase/peptidoglycan DD-endopeptidase Neighboring gene surface-exposed outer membrane lipoprotein Neighboring gene DUF2755 domain-containing inner membrane protein YaiY

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional characterization of SbmA, a bacterial inner membrane transporter required for importing the antimicrobial peptide Bac7(1-35). Runti G, et al. J Bacteriol, 2013 Dec. PMID 24078610, Free PMC Article
  2. Role of the Escherichia coli SbmA in the antimicrobial activity of proline-rich peptides. Mattiuzzo M, et al. Mol Microbiol, 2007 Oct. PMID 17725560
  3. Genetic analysis of the Sinorhizobium meliloti BacA protein: differential effects of mutations on phenotypes. LeVier K, et al. J Bacteriol, 2001 Nov. PMID 11591690, Free PMC Article
  4. Posttranslational modifications in microcin B17 define an additional class of DNA gyrase inhibitor. Yorgey P, et al. Proc Natl Acad Sci U S A, 1994 May 10. PMID 8183941, Free PMC Article
  5. Identification, mapping, cloning and characterization of a gene (sbmA) required for microcin B17 action on Escherichia coli K12. Laviña M, et al. J Gen Microbiol, 1986 Jun. PMID 3543211

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The yjiL-mdtM gene cluster mediates the antibacterial activity of proline-rich antimicrobial peptides overcoming Escherichia coli resistance induced by the missing SbmA transporter system.
    Title: Influence of the yjiL-mdtM Gene Cluster on the Antibacterial Activity of Proline-Rich Antimicrobial Peptides Overcoming Escherichia coli Resistance Induced by the Missing SbmA Transporter System.
  2. SbmA upregulation in a tolC mutant context was abolished in an rpoE-null strain.
    Title: The tolC locus affects the expression of sbmA through σE activity increase.
  3. Data show that inactivation of sbmA alone partially inhibited high-level tetracycline resistance and the addition of an sbmA mutation to a tolC::Tn10 mutant exacerbates this phenotype.
    Title: A combination of sbmA and tolC mutations in Escherichia coli K-12 Tn10-carrying strains results in hypersusceptibility to tetracycline.
  4. SbmA, is necessary for the transport of, and for susceptibility to, proline-rich antimicrobial peptides of eukaryotic origin.
    Title: Role of the Escherichia coli SbmA in the antimicrobial activity of proline-rich peptides.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables microcin transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables peptide transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables secondary active transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within microcin B17 transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within microcin transport EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within microcin transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within peptide transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptide transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within peptide transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to antibiotic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
peptide antibiotic/peptide nucleic acid transporter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    396639..397859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414911.1 peptide antibiotic/peptide nucleic acid transporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414911.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A7L7E9W0
    Conserved Domains (1) summary
    PRK11098
    Location:1 → 406
    PRK11098; peptide antibiotic transporter SbmA
Nucleotide Protein
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