xapA xanthosine phosphorylase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: xapA
Official Full Name: xanthosine phosphorylase
Primary source: ECOCYC:G85
Locus tag: b2407
See related: ASAP:ABE-0007927
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK2401; pndA
Summary: Guanosine and inosine are also substrates for XapA. [More information is available at EcoGene: EG20250]. The trimeric form is also active with less substrate specificity. [More information is available at EcoCyc: G85].
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Genomic context

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Sequence:: NC_000913.3 (2524045..2524878, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data indicated that xapA could convert nicotinamide to nicotinamide riboside in E. coli, albeit with relatively weak activity, indicating that xapA may contribute to a second NAD(+) salvage pathway from nicotinamide.
Title: New function for Escherichia coli xanthosine phophorylase (xapA): genetic and biochemical evidences on its participation in NAD(+) salvage from nicotinamide.
Data present a detailed biochemical characterization and the crystal structure of Escherichia coli purine nucleoside phosphorylase-II the product of the xapA gene
Title: Escherichia coli purine nucleoside phosphorylase II, the product of the xapA gene.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables guanosine phosphorylase activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables inosine nucleosidase activity	IDA Inferred from Direct Assay more info	PubMed
enables pentosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables purine-nucleoside phosphorylase activity	EXP Inferred from Experiment more info	PubMed
enables purine-nucleoside phosphorylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables purine-nucleoside phosphorylase activity	IDA Inferred from Direct Assay more info	PubMed
enables purine-nucleoside phosphorylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within NAD+ biosynthetic process via the salvage pathway	EXP Inferred from Experiment more info	PubMed
involved_in NAD+ biosynthetic process via the salvage pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in deoxyguanosine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in deoxyguanosine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in deoxyinosine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in deoxyinosine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in guanosine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in guanosine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in inosine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inosine catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nucleobase-containing small molecule interconversion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleobase-containing small molecule metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nucleobase-containing small molecule metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleoside metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein hexamerization	IDA Inferred from Direct Assay more info	PubMed
involved_in purine nucleoside catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in purine nucleoside catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within xanthosine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info