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frc [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946842, updated on 11-Sep-2024

Summary

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Official Symbol
frc
Primary source
ECOCYC:G7237
Locus tag
b2374
See related
ASAP:ABE-0007828
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2370; yfdW
Summary
Orthologous to O. formigenes Frc. [More information is available at EcoGene: EG14145]. YfdW (Frc) is a formyl-CoA transferase with sequence and structural similarity to Frc from Oxalobacter formigenes, a strictly anaerobic bacterium found in the mammalian gut . [More information is available at EcoCyc: G7237].
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Genomic context

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Sequence:
NC_000913.3 (2492004..2493254, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transport protein YfdV Neighboring gene oxalyl-CoA decarboxylase Neighboring gene protein YfdX Neighboring gene colanic acid synthesis putative lipoprotein YpdI

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential substrate specificity and kinetic behavior of Escherichia coli YfdW and Oxalobacter formigenes formyl coenzyme A transferase. Toyota CG, et al. J Bacteriol, 2008 Apr. PMID 18245280, Free PMC Article
  2. Structure of Escherichia coli YfdW, a type III CoA transferase. Gogos A, et al. Acta Crystallogr D Biol Crystallogr, 2004 Mar. PMID 14993676
  3. Medium-scale structural genomics: strategies for protein expression and crystallization. Vincentelli R, et al. Acc Chem Res, 2003 Mar. PMID 12641473
  4. A medium-throughput crystallization approach. Sulzenbacher G, et al. Acta Crystallogr D Biol Crystallogr, 2002 Dec. PMID 12454472
  5. YfdW and YfdU are required for oxalate-induced acid tolerance in Escherichia coli K-12. Fontenot EM, et al. J Bacteriol, 2013 Apr. PMID 23335415, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables CoA-transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables formyl-CoA transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables formyl-CoA transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to acidic pH IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oxalate catabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
formyl-CoA transferase
NP_416875.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2492004..2493254 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416875.1 formyl-CoA transferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416875.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1D8F583, A0A837B352, D8A5Y3, E1J8U8
    Conserved Domains (1) summary
    PRK05398
    Location:1 → 416
    PRK05398; formyl-coenzyme A transferase; Provisional
Nucleotide Protein
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