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emrK tripartite efflux pump membrane fusion protein EmrK [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946840, updated on 4-Feb-2026
Official Symbol
emrK
Official Full Name
tripartite efflux pump membrane fusion protein EmrK
Primary source
ECOCYC:G7233
Locus tag
b2368
See related
ASAP:ABE-0007808
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2364
Summary
EvgAS regulon. [More information is available at EcoGene: EG13282]. EmrK and EmrY show sequence similarity to EmrA and EmrB respectively. [More information is available at EcoCyc: G7233].
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Sequence:
NC_000913.3 (2482176..2483339, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene D-serine ammonia-lyase Neighboring gene tripartite efflux pump membrane subunit EmrY Neighboring gene protein EvgL Neighboring gene DNA-binding transcriptional activator EvgA Neighboring gene sensor histidine kinase EvgS

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Induction of multidrug resistance mechanism in Escherichia coli biofilms by interplay between tetracycline and ampicillin resistance genes. May T, et al. Antimicrob Agents Chemother, 2009 Nov. PMID 19721076, Free PMC Article
  2. Transcription of emrKY is regulated by the EvgA-EvgS two-component system in Escherichia coli K-12. Kato A, et al. Biosci Biotechnol Biochem, 2000 Jun. PMID 10923791
  3. Overexpression of the response regulator evgA of the two-component signal transduction system modulates multidrug resistance conferred by multidrug resistance transporters. Nishino K, et al. J Bacteriol, 2001 Feb. PMID 11157960, Free PMC Article
  4. Role of histone-like protein H-NS in multidrug resistance of Escherichia coli. Nishino K, et al. J Bacteriol, 2004 Mar. PMID 14973023, Free PMC Article
  5. Transcriptional regulation of drug efflux genes by EvgAS, a two-component system in Escherichia coli. Eguchi Y, et al. Microbiology (Reading), 2003 Oct. PMID 14523115

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables bile acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables xenobiotic transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in bile acid and bile salt transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bile acid and bile salt transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within bile acid and bile salt transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to antibiotic IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to antibiotic IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to antibiotic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in xenobiotic detoxification by transmembrane export across the cell outer membrane NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within xenobiotic detoxification by transmembrane export across the plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in periplasmic side of plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
tripartite efflux pump membrane fusion protein EmrK

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2482176..2483339 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416869.1 tripartite efflux pump membrane fusion protein EmrK

    See identical proteins and their annotated locations for NP_416869.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1V2G0N8
    Conserved Domains (1) summary
    TIGR00998
    Location:14 → 338
    8a0101; efflux pump membrane protein (multidrug resistance protein A)
Nucleotide Protein
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