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dsdA D-serine ammonia-lyase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946837, updated on 8-Apr-2026
Official Symbol
dsdA
Official Full Name
D-serine ammonia-lyase
Primary source
ECOCYC:EG10249
Locus tag
b2366
See related
ASAP:ABE-0007804
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2362
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Try the new Transcripts and proteins table
Sequence:
NC_000913.3 (2479202..2480530)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator DsdC Neighboring gene D-serine transporter Neighboring gene tripartite efflux pump membrane subunit EmrY Neighboring gene tripartite efflux pump membrane fusion protein EmrK

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Metagenome resource for D-serine utilization in a DsdA-disrupted Escherichia coli. Lim MY, et al. J Microbiol Biotechnol, 2011 Apr. PMID 21532320
  2. D-Serine dehydratase from Escherichia coli. Essential arginine residue at the pyridoxal 5'-phosphate binding site. Kazarinoff MN, et al. J Biol Chem, 1976 Oct 25. PMID 789365
  3. Sequence studies on D-serine dehydratase of Escherichia coli. Primary structure of the tryptic phosphopyridoxyl peptide and of the N-terminus. Schiltz E, et al. Eur J Biochem, 1976 Dec. PMID 795658
  4. Effect of potassium ion on the phosphorus-31 nuclear magnetic resonance spectrum of the pyridoxal 5'-phosphate cofactor of Escherichia coli D-serine dehydratase. Kojiro CL, et al. Arch Biochem Biophys, 1989 Jan. PMID 2643389
  5. The dsdA gene from Escherichia coli provides a novel selectable marker for plant transformation. Erikson O, et al. Plant Mol Biol, 2005 Feb. PMID 15830131

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Two alternative genetic resources for D-serine dehydratase were identified in DsdA-disrupted strain.
    Title: Metagenome resource for D-serine utilization in a DsdA-disrupted Escherichia coli.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Sequence of Escherichia coli D-serine dehydratase. Location of the pyridoxal-phosphate binding site.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables D-serine ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-serine ammonia-lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-serine ammonia-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydro-lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hydro-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in D-amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in D-serine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within D-serine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within D-serine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within detoxification of nitrogen compound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
D-serine ammonia-lyase
NP_416867.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2479202..2480530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416867.1 D-serine ammonia-lyase

    See identical proteins and their annotated locations for NP_416867.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S7EK81
    Conserved Domains (1) summary
    PRK02991
    Location:6 → 442
    PRK02991; D-serine dehydratase; Provisional
Nucleotide Protein
Heading Accession and Version

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