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fumA fumarase A [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946826, updated on 6-Jun-2024

Summary

Gene symbol
fumA
Gene description
fumarase A
Primary source
ASAP:ABE-0005392
Locus tag
b1612
See related
ECOCYC:EG10356
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1607
Summary
One of three isozymes in Escherichia coli, fumarase A is a Class I fumarase. [More information is available at EcoCyc: EG10356].
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Genomic context

Sequence:
NC_000913.3 (1686731..1688377, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene sensory histidine kinase RstB Neighboring gene DNA replication terminus site-binding protein Neighboring gene fumarase C Neighboring gene mannose-6-phosphate isomerase Neighboring gene DUF945 domain-containing protein YdgA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IDA
Inferred from Direct Assay
more info
PubMed 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables fumarate hydratase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fumarate hydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables fumarate hydratase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxaloacetate tautomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables oxaloacetate tautomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in generation of precursor metabolites and energy IEA
Inferred from Electronic Annotation
more info
 
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within tricarboxylic acid cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1686731..1688377 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416129.1 fumarase A [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416129.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376M7B2
    Conserved Domains (1) summary
    PRK15389
    Location:2537
    PRK15389; fumarate hydratase; Provisional