fumA fumarase A [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: fumA
Official Full Name: fumarase A
Primary source: ECOCYC:EG10356
Locus tag: b1612
See related: ASAP:ABE-0005392
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK1607
Summary: One of three isozymes in Escherichia coli, fumarase A is a Class I fumarase. [More information is available at EcoCyc: EG10356].
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The results show that Crp is an activator of fumA and fumC gene expression under various oxygen conditions and growth rates.
Title: Regulatory role of cAMP receptor protein over Escherichia coli fumarase genes.
The half-life of fumA mRNA was increased by fivefold when the growth rate was increased to 0.96/h.
Title: High growth rate downregulates fumA mRNA transcription but is dramatically compensated by its mRNA stability in Escherichia coli.
N-terminus verified by Edman degradation on mature peptide
Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IDA Inferred from Direct Assay more info	PubMed
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables fumarate hydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fumarate hydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables fumarate hydratase activity	IEA Inferred from Electronic Annotation more info
enables fumarate hydratase activity	NAS Non-traceable Author Statement more info	PubMed
enables hydro-lyase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables oxaloacetate tautomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables oxaloacetate tautomerase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in generation of precursor metabolites and energy	IEA Inferred from Electronic Annotation more info
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tricarboxylic acid cycle	IMP Inferred from Mutant Phenotype more info	PubMed