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fadL long-chain fatty acid outer membrane channel/bacteriophage T2 receptor [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946820, updated on 6-Jul-2026
Official Symbol
fadL
Official Full Name
long-chain fatty acid outer membrane channel/bacteriophage T2 receptor
Primary source
ECOCYC:EG10280
Locus tag
b2344
See related
ASAP:ABE-0007740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2338; ttr
Summary
FadL is an outer membrane protein involved with the uptake of long-chain fatty acids . [More information is available at EcoCyc: EG10280].
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Try the new Transcripts and proteins table
Sequence:
NC_000913.3 (2461306..2462646)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene multifunctional 3-hydroxyacyl-CoA dehydrogenase/3-hydroxyacyl-CoA epimerase/enoyl-CoA hydratase FadJ Neighboring gene 3-ketoacyl-CoA thiolase FadI Neighboring gene DUF406 domain-containing protein YfcZ Neighboring gene protein YfdF Neighboring gene intermembrane phospholipid transport system - outer membrane lipoprotein MlaA

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Purification and characterization of an outer membrane-bound protein involved in long-chain fatty acid transport in Escherichia coli. Black PN, et al. J Biol Chem, 1987 Jan 25. PMID 3027089
  2. The amino-terminal region of the long-chain fatty acid transport protein FadL contains an externally exposed domain required for bacteriophage T2 binding. Cristalli G, et al. Arch Biochem Biophys, 2000 May 15. PMID 10845710
  3. Osmoregulation of the fatty acid receptor gene fadL in Escherichia coli. Higashitani A, et al. Mol Gen Genet, 1993 Sep. PMID 8413182
  4. Crystal structure of the long-chain fatty acid transporter FadL. van den Berg B, et al. Science, 2004 Jun 4. PMID 15178802
  5. Bacterial long-chain fatty acid transport. Identification of amino acid residues within the outer membrane protein FadL required for activity. Kumar GB, et al. J Biol Chem, 1993 Jul 25. PMID 8340375

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CRP-cAMP complex directly activates expression of fadL and fadD genes.
    Title: Crosstalk of Escherichia coli FadR with global regulators in expression of fatty acid transport genes.
  2. Data show that high-affinity (submicromolar) substrate binding to the outer membrane long-chain fatty acid transporter FadL from Escherichia coli causes conformational changes in the N terminus that open up a channel for substrate diffusion.
    Title: Ligand-gated diffusion across the bacterial outer membrane.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: Amounts of proteins altered by mutations in the dnaA gene of Escherichia coli.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ligand-gated channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables long-chain fatty acid transporting porin activity EXP
Inferred from Experiment
more info
 PubMed 
enables long-chain fatty acid transporting porin activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid transporting porin activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within long-chain fatty acid transport EXP
Inferred from Experiment
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
long-chain fatty acid outer membrane channel/bacteriophage T2 receptor

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2461306..2462646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416846.2 long-chain fatty acid outer membrane channel/bacteriophage T2 receptor

    See identical proteins and their annotated locations for NP_416846.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7LBJ8
    Conserved Domains (1) summary
    PRK10716
    Location:1 → 446
    PRK10716; long-chain fatty acid transporter FadL
Nucleotide Protein
Heading Accession and Version

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