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fecD ferric citrate ABC transporter membrane subunit FecD [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946816, updated on 17-Jul-2025
Official Symbol
fecD
Official Full Name
ferric citrate ABC transporter membrane subunit FecD
Primary source
ECOCYC:EG10289
Locus tag
b4288
See related
ASAP:ABE-0014059
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4278
Summary
Probable false positive lipoprotein prediction, 9 CM TMs predicted, Cys not conserved. [More information is available at EcoGene: EG10289]. FecD is one of two (along with FecC) integral membrane protein components of the iron dicitrate ABC transporter. [More information is available at EcoCyc: EG10289].
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Sequence:
NC_000913.3 (4511458..4512414, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ferric citrate ABC transporter ATP binding subunit Neighboring gene ferric citrate ABC transporter membrane subunit FecC Neighboring gene ferric citrate ABC transporter periplasmic binding protein Neighboring gene ferric citrate outer membrane transporter

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Citrate-dependent iron transport system in Escherichia coli K-12. Hussein S, et al. Eur J Biochem, 1981 Jul. PMID 6268411
  2. Genetics of the iron dicitrate transport system of Escherichia coli. Pressler U, et al. J Bacteriol, 1988 Jun. PMID 2836368, Free PMC Article
  3. Ferric citrate transport in Escherichia coli requires outer membrane receptor protein fecA. Wagegg W, et al. J Bacteriol, 1981 Jan. PMID 7007312, Free PMC Article
  4. Localization of the entire fec region at 97.3 minutes on the Escherichia coli K-12 chromosome. Veitinger S, et al. J Bacteriol, 1992 Jun. PMID 1592838, Free PMC Article
  5. Transmembrane transcriptional control (surface signalling) of the Escherichia coli Fec type. Braun V, et al. FEMS Microbiol Rev, 2005 Sep. PMID 16102597

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SDS results suggest cross-linking of FecB(E93C) to FecD(R54C) and that FecB(E93) is contained in the region that binds to FecD and FecB(E222) in the region that binds to FecC.
    Title: Docking of the periplasmic FecB binding protein to the FecCD transmembrane proteins in the ferric citrate transport system of Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables iron chelate transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular iron ion homeostasis NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in iron import into cell NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in iron ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in siderophore-iron import into cell IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within siderophore-iron import into cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Preferred Names
ferric citrate ABC transporter membrane subunit FecD
NP_418708.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4511458..4512414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418708.1 ferric citrate ABC transporter membrane subunit FecD

    See identical proteins and their annotated locations for NP_418708.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0H3MNJ1
    Conserved Domains (1) summary
    PRK09777
    Location:1 → 318
    fecD; Fe(3+) dicitrate ABC transporter permease subunit FecD
Nucleotide Protein
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