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sixA phosphohistidine phosphatase SixA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946815, updated on 26-Mar-2025
Official Symbol
sixA
Official Full Name
phosphohistidine phosphatase SixA
Primary source
ECOCYC:G7211
Locus tag
b2340
See related
ASAP:ABE-0007720
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2334; yfcW
Summary
SixA overexpression also interferes with BarA Hpt function (Ogina, 1998). [More information is available at EcoGene: EG14126]. The sixA gene encodes a phosphohistidine phosphatase that specifically removes the phosphoryl group from the His717 residue of ArcB . [More information is available at EcoCyc: G7211].
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Sequence:
NC_000913.3 (2456327..2456812, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene putative fimbrial protein YfcV Neighboring gene 3-hydroxyacyl-CoA dehydrogenase FadJ Neighboring gene 3-ketoacyl-CoA thiolase FadI Neighboring gene DUF406 domain-containing protein YfcZ

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The phosphohistidine phosphatase SixA dephosphorylates the phosphocarrier NPr. Schulte JE, et al. J Biol Chem, 2021 Jan-Jun. PMID 33199374, Free PMC Article
  2. Crystallographic characterization of a novel protein SixA which exhibits phospho-histidine phosphatase activity in the multistep His-Asp phosphorelay. Hamada K, et al. Acta Crystallogr D Biol Crystallogr, 1999 Jan. PMID 10089421
  3. The Phosphohistidine Phosphatase SixA Targets a Phosphotransferase System. Schulte JE, et al. mBio, 2018 Nov 27. PMID 30482831, Free PMC Article
  4. Crystal structure of the protein histidine phosphatase SixA in the multistep His-Asp phosphorelay. Hamada K, et al. Genes Cells, 2005 Jan. PMID 15670209
  5. An Escherichia coli protein that exhibits phosphohistidine phosphatase activity towards the HPt domain of the ArcB sensor involved in the multistep His-Asp phosphorelay. Ogino T, et al. Mol Microbiol, 1998 Feb. PMID 9489669

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein histidine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein histidine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein histidine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein modification process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein modification process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of phosphorelay signal transduction system IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of phosphorelay signal transduction system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
phosphohistidine phosphatase SixA

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2456327..2456812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416842.1 phosphohistidine phosphatase SixA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416842.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S0FP52
    Conserved Domains (1) summary
    PRK10848
    Location:1 → 159
    PRK10848; phosphohistidine phosphatase SixA
Nucleotide Protein
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