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gdhA glutamate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946802, updated on 4-Feb-2026
Official Symbol
gdhA
Official Full Name
glutamate dehydrogenase
Primary source
ECOCYC:EG10372
Locus tag
b1761
See related
ASAP:ABE-0005865
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1759
Summary
Glutamate dehydrogenase catalyzes the amination step in the ATP-dependent glutamate synthase pathway. [More information is available at EcoCyc: EG10372].
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Sequence:
NC_000913.3 (1842371..1843714)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene CDP-alcohol phosphatidyltransferase domain-containing protein YnjF Neighboring gene 5-hydroxy-CTP diphosphatase Neighboring gene DUF1496 domain-containing protein YnjH Neighboring gene DUF1266 domain-containing protein YnjI Neighboring gene DNA topoisomerase III

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Nucleotide sequence of the promoter and amino-terminal coding region of the glutamate dehydrogenase structural gene of Escherichia coli. Valle F, et al. Gene, 1983 Aug. PMID 6225701
  2. Pathway choice in glutamate synthesis in Escherichia coli. Helling RB. J Bacteriol, 1998 Sep. PMID 9721297, Free PMC Article
  3. The gdhA1 point mutation in Escherichia coli K12 CLR207 alters a key lysine residue of glutamate dehydrogenase. Jones KM, et al. Mol Gen Genet, 1993 Aug. PMID 8355660
  4. Crystallization of the NADP(+)-dependent glutamate dehydrogenase from Escherichia coli. Korber FC, et al. J Mol Biol, 1993 Dec 20. PMID 8263929
  5. Isolation and cloning of the gene from Escherichia coli encoding glutamate decarboxylase. De Biase D, et al. Biotechnol Appl Biochem, 1993 Oct. PMID 8251111

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EcGDH deviates from Michaelis-Menten kinetics, exhibiting apparent mild negative co-operativity with both l-glutamate and NADP+.
    Title: Apparent negative co-operativity and substrate inhibition in overexpressed glutamate dehydrogenase from Escherichia coli.
  2. N-terminus verified by Edman degradation on complete protein
    Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-glutamate dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-glutamate dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-glutamate dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables L-glutamate dehydrogenase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
  
enables guanosine tetraphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-glutamate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within L-glutamate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-glutamate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutamate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
glutamate dehydrogenase
NP_416275.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1842371..1843714
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416275.1 glutamate dehydrogenase

    See identical proteins and their annotated locations for NP_416275.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376WXP3, A0A895NQZ6
    Conserved Domains (1) summary
    PRK09414
    Location:1 → 447
    PRK09414; NADP-specific glutamate dehydrogenase
Nucleotide Protein
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