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uxuB D-mannonate oxidoreductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946795, updated on 19-Sep-2024

Summary

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Official Symbol
uxuB
Official Full Name
D-mannonate oxidoreductase
Primary source
ECOCYC:EG20248
Locus tag
b4323
See related
ASAP:ABE-0014175
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK4314
Summary
UxuR regulon. [More information is available at EcoGene: EG20248]. D-mannonate oxidoreductase is an enzyme of the D-glucuronate degradation pathway, reducing D-fructuronate to D-mannonate. [More information is available at EcoCyc: EG20248].
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Genomic context

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Sequence:
NC_000913.3 (4552901..4554361)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene fructuronate transporter Neighboring gene D-mannonate dehydratase Neighboring gene DNA-binding transcriptional repressor UxuR Neighboring gene DUF2686 domain-containing protein YjiC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Studies of mutations in glucuronate catabolism in Escherichia coli K12 (author's transl)]. Robert-Baudouy JM, et al. Mol Gen Genet, 1974. PMID 4603847
  2. [D-mannonate: NAD oxidoreductase from Escherichia coli K12. Purification, properties and specificity]. Portalier RC, et al. Eur J Biochem, 1972 Mar 27. PMID 4402996
  3. [D-mannonate: NAD-oxidoreductase from Escherichia coli K12. Kinetic studies of the enzymatic mechanism]. Portalier RC. Eur J Biochem, 1972 Oct. PMID 4351435
  4. "Hit-and-run" mechanism for D-glucuronate reduction catalyzed by D-mannonate:NAD oxidoreductase of Escherichia coli. Mandrand-Berthelot MA, et al. Biochim Biophys Acta, 1977 Jul 8. PMID 195622
  5. Uronic acid metabolism in bacteria. II. Purification and properties of D-altronic acid and D-mannonic acid dehydrogenases in Escherichia coli. HICKMAN J, et al. J Biol Chem, 1960 Jun. PMID 14401695

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables fructuronate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructuronate reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables fructuronate reductase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in D-glucuronate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within D-glucuronate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mannitol metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
D-mannonate oxidoreductase
NP_418743.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    4552901..4554361
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_418743.1 D-mannonate oxidoreductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_418743.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A827QTD8
    Conserved Domains (1) summary
    PRK15037
    Location:1 → 486
    PRK15037; D-mannonate oxidoreductase; Provisional
Nucleotide Protein
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