U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

hisM lysine/arginine/ornithine ABC transporter/histidine ABC transporter, membrane subunit HisM [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946790, updated on 4-Feb-2026
Official Symbol
hisM
Official Full Name
lysine/arginine/ornithine ABC transporter/histidine ABC transporter, membrane subunit HisM
Primary source
ECOCYC:EG10007
Locus tag
b2307
See related
ASAP:ABE-0007613
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2301
Summary
HisPMQJ is an ATP-dependent histidine transport system that is a member of the ATP-Binding Cassette (ABC) Superfamily of transporters . [More information is available at EcoCyc: EG10007].
Try the new Gene page
Try the new Transcripts and proteins table
Sequence:
NC_000913.3 (2424517..2425233, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene recombination-promoting nuclease RpnB Neighboring gene lysine/arginine/ornithine ABC transporter/histidine ABC transporter, ATP binding subunit Neighboring gene lysine/arginine/ornithine ABC transporter/histidine ABC transporter, membrane subunit HisQ Neighboring gene histidine ABC transporter periplasmic binding protein Neighboring gene lysine/arginine/ornithine ABC transporter periplasmic binding protein

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A chimeric nucleotide-binding protein, encoded by a hisP-malK hybrid gene, is functional in maltose transport in Salmonella typhimurium. Schneider E, et al. Mol Microbiol, 1991 Jun. PMID 1787792
  2. Sequence of the complete P protein gene and part of the M protein gene from the histidine transport operon of Escherichia coli compared to that of Salmonella typhimurium. Kraft R, et al. Nucleic Acids Res, 1987 Oct 26. PMID 3313284, Free PMC Article
  3. Reconstitution of a bacterial periplasmic permease in proteoliposomes and demonstration of ATP hydrolysis concomitant with transport. Bishop L, et al. Proc Natl Acad Sci U S A, 1989 Sep. PMID 2674940, Free PMC Article
  4. Two periplasmic transport proteins which interact with a common membrane receptor show extensive homology: complete nucleotide sequences. Higgins CF, et al. Proc Natl Acad Sci U S A, 1981 Oct. PMID 6273842, Free PMC Article
  5. Characterization of transport through the periplasmic histidine permease using proteoliposomes reconstituted by dialysis. Liu CE, et al. J Biol Chem, 1997 Jan 10. PMID 8995374

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-histidine import across plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in amino acid import across plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in amino acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ATP-binding cassette (ABC) transporter complex IEA
Inferred from Electronic Annotation
more info
  
part_of ATP-binding cassette (ABC) transporter complex RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Preferred Names
lysine/arginine/ornithine ABC transporter/histidine ABC transporter, membrane subunit HisM
NP_416810.1

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2424517..2425233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416810.1 lysine/arginine/ornithine ABC transporter/histidine ABC transporter, membrane subunit HisM

    See identical proteins and their annotated locations for NP_416810.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A377DPB0
    Conserved Domains (1) summary
    PRK15069
    Location:1 → 234
    PRK15069; histidine ABC transporter permease HisM
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.