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nlpE sensor lipoprotein NlpE [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946782, updated on 19-Nov-2025
Official Symbol
nlpE
Official Full Name
sensor lipoprotein NlpE
Primary source
ECOCYC:EG12137
Locus tag
b0192
See related
ASAP:ABE-0000652
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cutF; ECK0192
Summary
NlpE is an outer membrane lipoprotein . [More information is available at EcoCyc: EG12137].
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Sequence:
NC_000913.3 (215269..215979)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene modulator of Rho-dependent transcription termination Neighboring gene PF06786 family protein YaeP Neighboring gene uncharacterized protein YaeQ Neighboring gene peptidyl-tRNA hydrolase, ribosome rescue factor Neighboring gene peptidase C92 family protein YaeF Neighboring gene proline--tRNA ligase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A Stress Response Monitoring Lipoprotein Trafficking to the Outer Membrane. May KL, et al. mBio, 2019 May 28. PMID 31138744, Free PMC Article
  2. Redefining the essential trafficking pathway for outer membrane lipoproteins. Grabowicz M, et al. Proc Natl Acad Sci U S A, 2017 May 2. PMID 28416660, Free PMC Article
  3. The Surface Sensor NlpE of Enterohemorrhagic Escherichia coli Contributes to Regulation of the Type III Secretion System and Flagella by the Cpx Response to Adhesion. Shimizu T, et al. Infect Immun, 2016 Feb. PMID 26644384, Free PMC Article
  4. Structural studies of the Cpx pathway activator NlpE on the outer membrane of Escherichia coli. Hirano Y, et al. Structure, 2007 Aug. PMID 17698001
  5. The response to extracytoplasmic stress in Escherichia coli is controlled by partially overlapping pathways. Connolly L, et al. Genes Dev, 1997 Aug 1. PMID 9271123, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NlpE activates Cpx to protect against lipoprotein trafficking stress
    Title: A Stress Response Monitoring Lipoprotein Trafficking to the Outer Membrane.
  2. Overall, these data demonstrate that NlpE acts as a sentinel for two important envelope biogenesis processes, namely, lipoprotein sorting and oxidative folding, and they further establish NlpE as a bona fide member of the CpxA-CpxR two-component system.
    Title: The Lipoprotein NlpE Is a Cpx Sensor That Serves as a Sentinel for Protein Sorting and Folding Defects in the Escherichia coli Envelope.
  3. Sensing of adhesion signals via NlpE is important for regulation of the expression of the type III secretion system and flagella in enterohemorrhagic Escherichia coli during infection
    Title: The Surface Sensor NlpE of Enterohemorrhagic Escherichia coli Contributes to Regulation of the Type III Secretion System and Flagella by the Cpx Response to Adhesion.
  4. The nonlipidated Cys1Ala mutant of NlpE with a C-terminal His tag from Escherichia coli was constructed, overexpressed and purified. The tetragonal crystals diffracted to 2.8 A resolution and belong to space group P4(3)2(1)2.
    Title: Purification, crystallization and preliminary X-ray crystallographic analysis of the outer membrane lipoprotein NlpE from Escherichia coli.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to cell envelope stress EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within regulation of cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within stress response to copper ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
sensor lipoprotein NlpE

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    215269..215979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414734.1 sensor lipoprotein NlpE

    See identical proteins and their annotated locations for NP_414734.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A6D0IF33
    Conserved Domains (1) summary
    PRK10523
    Location:1 → 233
    PRK10523; envelope stress response activation lipoprotein NlpE
Nucleotide Protein
Heading Accession and Version

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