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yfbR dCMP phosphohydrolase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946771, updated on 9-Mar-2022

Summary

Gene symbol
yfbR
Gene description
dCMP phosphohydrolase
Primary source
ASAP:ABE-0007563
Locus tag
b2291
See related
ECOCYC:G7185
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2285
Summary
Divalent metal required for catalytic activity. [More information is available at EcoGene: EG14102]. YfbR is a 5'-deoxynucleotidase that functions as a dCMP phosphohydrolase in a salvage pathway for the synthesis of dUMP in a dcd deoA mutant . [More information is available at EcoCyc: G7185].
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Genomic context

Sequence:
NC_000913.3 (2408862..2409461)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional dual regulator LrhA Neighboring gene glutamate--pyruvate aminotransferase AlaA Neighboring gene putative transporter YfbS Neighboring gene hexitol phosphatase A

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables 5'-deoxynucleotidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 5'-deoxynucleotidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 5'-deoxynucleotidase activity IEA
Inferred from Electronic Annotation
more info
 
enables cobalt ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within dUMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pyrimidine deoxyribonucleotide salvage IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dCMP phosphohydrolase
NP_416794.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2408862..2409461
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416794.1 dCMP phosphohydrolase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416794.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P76491
    Conserved Domains (1) summary
    PRK03826
    Location:2196
    PRK03826; 5'-nucleotidase; Provisional