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nuoC NADH:quinone oxidoreductase subunit CD [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946759, updated on 26-Mar-2025
Official Symbol
nuoC
Official Full Name
NADH:quinone oxidoreductase subunit CD
Primary source
ECOCYC:EG12084
Locus tag
b2286
See related
ASAP:ABE-0007549
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2280; nuoD
Summary
Leif (1995) find the starting amino acids at codon +4 (MVNN), in conflict with the more recent data of David (2002), which does not include these 4 amino acids and the initial Met. [More information is available at EcoGene: EG12084]. NuoC is part of the connecting fragment of NADH dehydrogenase I . [More information is available at EcoCyc: EG12084].
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Sequence:
NC_000913.3 (2402055..2403845, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene NADH:quinone oxidoreductase subunit H Neighboring gene NADH:quinone oxidoreductase subunit G Neighboring gene NADH:quinone oxidoreductase subunit F Neighboring gene NADH:quinone oxidoreductase subunit E Neighboring gene NADH:quinone oxidoreductase subunit B Neighboring gene NADH:quinone oxidoreductase subunit A

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Pivotal roles of three conserved carboxyl residues of the NuoC (30k) segment in the structural integrity of proton-translocating NADH-quinone oxidoreductase from Escherichia coli. Castro-Guerrero N, et al. Biochemistry, 2010 Nov 30. PMID 20979355, Free PMC Article
  2. Role of the conserved arginine 274 and histidine 224 and 228 residues in the NuoCD subunit of complex I from Escherichia coli. Belevich G, et al. Biochemistry, 2007 Jan 16. PMID 17209562
  3. Energy complexes are apparently associated with the switch-motor complex of bacterial flagella. Zarbiv G, et al. J Mol Biol, 2012 Feb 17. PMID 22210351, Free PMC Article
  4. Chemical and NADH-induced, ROS-dependent, cross-linking between subunits of complex I from Escherichia coli and Thermus thermophilus. Berrisford JM, et al. Biochemistry, 2008 Sep 30. PMID 18771280
  5. Mutations in NADH:ubiquinone oxidoreductase of Escherichia coli affect growth on mixed amino acids. Prüss BM, et al. J Bacteriol, 1994 Apr. PMID 8157582, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Isolation and characterization of the proton-translocating NADH: ubiquinone oxidoreductase from Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to NADH dehydrogenase (ubiquinone) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADH dehydrogenase (ubiquinone) activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to NADH dehydrogenase (ubiquinone) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to NADH dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADH:ubiquinone reductase (non-electrogenic) activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables quinone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in respiratory electron transport chain IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of NADH dehydrogenase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NADH dehydrogenase complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
part_of respiratory chain complex I IDA
Inferred from Direct Assay
more info
 PubMed 
part_of respiratory chain complex I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of respiratory chain complex I NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
NADH:quinone oxidoreductase subunit CD
NP_416789.2

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2402055..2403845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416789.2 NADH:quinone oxidoreductase subunit CD [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416789.2

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q0TFG0
    UniProtKB/TrEMBL
    A0A0A0FSU8, A0AAN4NSZ5
    Conserved Domains (1) summary
    PRK11742
    Location:21 → 596
    PRK11742; bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional
Nucleotide Protein
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