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menE o-succinylbenzoate--CoA ligase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946741, updated on 23-Apr-2026
Official Symbol
menE
Official Full Name
o-succinylbenzoate--CoA ligase
Primary source
ECOCYC:EG12437
Locus tag
b2260
See related
ASAP:ABE-0007471
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2254
Summary
O-succinylbenzoate-CoA ligase catalyzes the formation of an intermediate in menaquinone biosynthesis, o-succinylbenzoyl-CoA . [More information is available at EcoCyc: EG12437].
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Sequence:
NC_000913.3 (2373648..2375003, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase Neighboring gene undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnE subunit Neighboring gene undecaprenyl-phosphate-alpha-L-Ara4N flippase - ArnF subunit Neighboring gene signal transduction protein PmrD Neighboring gene o-succinylbenzoate synthase Neighboring gene 1,4-dihydroxy-2-naphthoyl-CoA synthase Neighboring gene 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase Neighboring gene 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents. Matarlo JS, et al. Biochemistry, 2015 Oct 27. PMID 26394156, Free PMC Article
  2. Vitamin K2 (menaquinone) biosynthesis in Escherichia coli: evidence for the presence of an essential histidine residue in o-succinylbenzoyl coenzyme A synthetase. Bhattacharyya DK, et al. J Bacteriol, 1997 Oct. PMID 9324253, Free PMC Article
  3. Menaquinone (vitamin K2) biosynthesis: overexpression, purification, and properties of o-succinylbenzoyl-coenzyme A synthetase from Escherichia coli. Kwon O, et al. J Bacteriol, 1996 Dec. PMID 8955296, Free PMC Article
  4. Role of menaquinone biosynthesis genes in selenate reduction by Enterobacter cloacae SLD1a-1 and Escherichia coli K12. Ma J, et al. Environ Microbiol, 2009 Jan. PMID 18811645
  5. Characterization of Escherichia coli men mutants defective in conversion of o-succinylbenzoate to 1,4-dihydroxy-2-naphthoate. Shaw DJ, et al. J Bacteriol, 1982 Dec. PMID 6754698, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. X-ray crystallography and site-directed mutagenesis confirm the importance of a conserved arginine for binding the o-succinylbenzoyl carboxylate.
    Title: Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents.
  2. The results showed that E. coli K12 carrying a deletion of either the menD, menC or menE gene was unable to reduce selenate.
    Title: Role of menaquinone biosynthesis genes in selenate reduction by Enterobacter cloacae SLD1a-1 and Escherichia coli K12.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acid-thiol ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables o-succinylbenzoate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables o-succinylbenzoate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables o-succinylbenzoate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in menaquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in menaquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within menaquinone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
o-succinylbenzoate--CoA ligase
NP_416763.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2373648..2375003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416763.1 o-succinylbenzoate--CoA ligase

    See identical proteins and their annotated locations for NP_416763.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376WVJ5
    Conserved Domains (1) summary
    PRK09029
    Location:1 → 451
    PRK09029; O-succinylbenzoic acid--CoA ligase; Provisional
Nucleotide Protein
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