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glpC anaerobic glycerol-3-phosphate dehydrogenase subunit C [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946735, updated on 4-Feb-2026
Official Symbol
glpC
Official Full Name
anaerobic glycerol-3-phosphate dehydrogenase subunit C
Primary source
ECOCYC:EG10393
Locus tag
b2243
See related
ASAP:ABE-0007426
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2235
Summary
glpC was also identified as increasing organic solvent tolerance. [More information is available at EcoGene: EG10393]. The GlpABC enzyme is loosely associated with the cell membrane. [More information is available at EcoCyc: EG10393].
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Sequence:
NC_000913.3 (2355521..2356711)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene sn-glycerol 3-phosphate:phosphate antiporter Neighboring gene anaerobic glycerol-3-phosphate dehydrogenase subunit A Neighboring gene anaerobic glycerol-3-phosphate dehydrogenase subunit B Neighboring gene inactive recombination-promoting nuclease-like protein RpnE Neighboring gene pseudo

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Discovery of glpC, an organic solvent tolerance-related gene in Escherichia coli, using gene expression profiles from DNA microarrays. Shimizu K, et al. Appl Environ Microbiol, 2005 Feb. PMID 15691972, Free PMC Article
  2. Enzyme complex which couples glycerol-3-phosphate dehydrogenation to fumarate reduction in Escherichia coli. Miki K, et al. J Bacteriol, 1973 May. PMID 4574699, Free PMC Article
  3. Use of phi(glp-lac) in studies of respiratory regulation of the Escherichia coli anaerobic sn-glycerol-3-phosphate dehydrogenase genes (glpAB). Kuritzkes DR, et al. J Bacteriol, 1984 Feb. PMID 6363389, Free PMC Article
  4. A requirement for anaerobically induced redox functions during aerobic growth of Escherichia coli with serine, glycine and leucine as carbon source. Lan J, et al. Res Microbiol, 2003 Apr. PMID 12706508
  5. Physiological role of GlpB of anaerobic glycerol-3-phosphate dehydrogenase of Escherichia coli. Varga ME, et al. Biochem Cell Biol, 1995 Mar-Apr. PMID 7576488

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Nucleotide sequence and gene-polypeptide relationships of the glpABC operon encoding the anaerobic sn-glycerol-3-phosphate dehydrogenase of Escherichia coli K-12.
  2. remarkably increased the tolerance to organic solvents
    Title: Discovery of glpC, an organic solvent tolerance-related gene in Escherichia coli, using gene expression profiles from DNA microarrays.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables glycerol-3-phosphate dehydrogenase (quinone) activity EXP
Inferred from Experiment
more info
 PubMed 
enables glycerol-3-phosphate dehydrogenase (quinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables iron-sulfur cluster binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables metal ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anaerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaerobic respiration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within anaerobic respiration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in anaerobic respiration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within electron transport chain IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycerol catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol-3-phosphate catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of glycerol-3-phosphate dehydrogenase (FAD) complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
anaerobic glycerol-3-phosphate dehydrogenase subunit C
NP_416746.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2355521..2356711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416746.1 anaerobic glycerol-3-phosphate dehydrogenase subunit C

    See identical proteins and their annotated locations for NP_416746.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2H4TXJ0
    Conserved Domains (1) summary
    TIGR03379
    Location:3 → 396
    glycerol3P_GlpC; glycerol-3-phosphate dehydrogenase, anaerobic, C subunit
Nucleotide Protein
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