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ykfI toxin of the YkfI-YafW toxin-antitoxin system [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946726, updated on 19-Sep-2024

Summary

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Official Symbol
ykfI
Official Full Name
toxin of the YkfI-YafW toxin-antitoxin system
Primary source
ECOCYC:G6120
Locus tag
b0245
See related
ASAP:ABE-0000836
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0246
Summary
ykfI, ypjF and yeeV are paralogs. [More information is available at EcoGene: EG14333]. Episomal expression of ykfI causes inhibition of cell growth and decreased viability, compared to wild type , and this phenotype is suppressed by coexpression of yafW . [More information is available at EcoCyc: G6120].
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Genomic context

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Sequence:
NC_000913.3 (263328..263669, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene pseudo Neighboring gene antitoxin of the YkfI-YafW toxin-antitoxin pair Neighboring gene DUF987 domain-containing protein YkfH

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Temporal gene-expression in Escherichia coli K-12 biofilms. Domka J, et al. Environ Microbiol, 2007 Feb. PMID 17222132
  2. Prophages and bacterial genomics: what have we learned so far? Casjens S. Mol Microbiol, 2003 Jul. PMID 12886937
  3. A novel family of Escherichia coli toxin-antitoxin gene pairs. Brown JM, et al. J Bacteriol, 2003 Nov. PMID 14594833, Free PMC Article
  4. A functional update of the Escherichia coli K-12 genome. Serres MH, et al. Genome Biol, 2001. PMID 11574054, Free PMC Article
  5. The binary protein-protein interaction landscape of Escherichia coli. Rajagopala SV, et al. Nat Biotechnol, 2014 Mar. PMID 24561554, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
toxin of the YkfI-YafW toxin-antitoxin system

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    263328..263669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414779.1 toxin of the YkfI-YafW toxin-antitoxin system [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414779.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P77692
    Conserved Domains (1) summary
    pfam06755
    Location:1 → 108
    CbtA_toxin; CbtA_toxin of type IV toxin-antitoxin system
Nucleotide Protein
Heading Accession and Version

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