acnA aconitate hydratase 1 [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: acnA
Official Full Name: aconitate hydratase 1
Primary source: ECOCYC:EG11325
Locus tag: b1276
See related: ASAP:ABE-0004283
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: acn; ECK1271
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NC_000913.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The structural state of AcnA by the chemical crosslinking and small-angle X-ray scattering was analyzed.
Title: Cooperativity of two active sites in bacterial homodimeric aconitases.
N-terminus verified by Edman degradation on mature peptide
Title: The aconitase of Escherichia coli: purification of the enzyme and molecular cloning and map location of the gene (acn).

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables 4 iron, 4 sulfur cluster binding	IDA Inferred from Direct Assay more info	PubMed
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables aconitate hydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aconitate hydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables aconitate hydratase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables iron-responsive element binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anaerobic respiration	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular respiration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glyoxylate cycle	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tricarboxylic acid cycle	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed