ompC outer membrane porin C [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Gene symbol: ompC
Gene description: outer membrane porin C
Primary source: ECOCYC:EG10670
Locus tag: b2215
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK2207; meoA; par
Summary: Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG10670]. OmpC is a member of the GMP family. [More information is available at EcoCyc: EG10670].
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Genomic context

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Sequence:: NC_000913.3 (2311646..2312749, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LamB, OmpC, and the Core Lipopolysaccharide of Escherichia coli K-12 Function as Receptors of Bacteriophage Bp7.
Title: LamB, OmpC, and the Core Lipopolysaccharide of Escherichia coli K-12 Function as Receptors of Bacteriophage Bp7.
findings reveal an unknown OmpC-dependent mechanism of ethanol tolerance in a manner of EnvZ/OmpR regulation.
Title: Identification of ethanol tolerant outer membrane proteome reveals OmpC-dependent mechanism in a manner of EnvZ/OmpR regulation in Escherichia coli.
Klebsiella pneumoniae OmpK35 and OmpK36 produced larger more permeable channels than their Escherichia coli homologs OmpF and OmpC.
Title: Klebsiella pneumoniae Major Porins OmpK35 and OmpK36 Allow More Efficient Diffusion of β-Lactams than Their Escherichia coli Homologs OmpF and OmpC.
established that OmpC is an additional component of the Mla system; the OmpC-MlaA complex may function to remove phospholipids directly from the outer leaflet to maintain outer membrane lipid asymmetry;work reveals a novel function for the general diffusion channel OmpC in lipid transport
Title: Osmoporin OmpC forms a complex with MlaA to maintain outer membrane lipid asymmetry in Escherichia coli.
Studied the rate of entry (association) and exit (dissociation) of six antibiotics to/from reconstituted E. coli porin OmpC. WaterMap was used to estimate the total water transfer energies resulting from transient occupation by each antibiotic.
Title: The translocation kinetics of antibiotics through porin OmpC: insights from structure-based solvation mapping using WaterMap.
N-terminus verified by Edman degradation on mature peptide
Title: Extraction of membrane proteins by differential solubilization for separation using two-dimensional gel electrophoresis.
OmpF or OmpC can function in the translocon complex of the colicin E2 R-domain and its BtuB receptor
Title: Structure of the complex of the colicin E2 R-domain and its BtuB receptor. The outer membrane colicin translocon.
for the classical porins OmpF and OmpC, our results show that the Cpx envelope stress response system plays a role in regulating their expression
Title: The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
X ray structure of OmpC complexed with lactoferrin
Title: High-resolution diffraction from crystals of a membrane-protein complex: bacterial outer membrane protein OmpC complexed with the antibacterial eukaryotic protein lactoferrin.
OmpR allows distinct stepwise regulation of ompF and ompC transcription, which minimizes their overlapping expression upon changes in the medium osmolarity to achieve the reciprocal expression of ompF and ompC
Title: Transcription regulation of ompF and ompC by a single transcription factor, OmpR.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GO

Function	Evidence Code	Pubs
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables porin activity	IDA Inferred from Direct Assay more info	PubMed
enables porin activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables virus receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEP Inferred from Expression Pattern more info	PubMed
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated virion attachment to host cell	IDA Inferred from Direct Assay more info	PubMed
involved_in viral entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell outer membrane	IEA Inferred from Electronic Annotation more info
located_in cellular anatomical entity	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of pore complex	IEA Inferred from Electronic Annotation more info
part_of pore complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: outer membrane porin C

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

2311646..2312749 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_416719.1 outer membrane porin C [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_416719.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

P06996

Conserved Domains (1) summary

PRK10554
Location:14 → 367

PRK10554; outer membrane porin protein C; Provisional