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flgM anti-sigma factor for FliA (sigma(28)) [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946684, updated on 6-Jul-2026
Official Symbol
flgM
Official Full Name
anti-sigma factor for FliA (sigma(28))
Primary source
ECOCYC:G369
Locus tag
b1071
See related
ASAP:ABE-0003634
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1056
Summary
Flk prevents premature FlgM secretion. [More information is available at EcoGene: EG12664]. FlgM function has been extensively studied in Salmonella typhimurium. [More information is available at EcoCyc: G369].
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Sequence:
NC_000913.3 (1129835..1130128, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipid II flippase MurJ Neighboring gene flagellar biosynthesis protein FlgN Neighboring gene flagellar basal body P-ring formation protein FlgA Neighboring gene flagellar basal-body rod protein FlgB

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A novel transcriptional regulation mechanism in the flagellar regulon of Salmonella typhimurium: an antisigma factor inhibits the activity of the flagellum-specific sigma factor, sigma F. Ohnishi K, et al. Mol Microbiol, 1992 Nov. PMID 1453955
  2. Sensing structural intermediates in bacterial flagellar assembly by export of a negative regulator. Hughes KT, et al. Science, 1993 Nov 19. PMID 8235660
  3. FlgM gains structure in living cells. Dedmon MM, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12271132, Free PMC Article
  4. Stochastic assembly of chemoreceptor clusters in Escherichia coli. Thiem S, et al. Mol Microbiol, 2008 Jun. PMID 18476921
  5. A Salmonella typhimurium virulence gene linked to flg. Carsiotis M, et al. Infect Immun, 1989 Nov. PMID 2680969, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FlgM modulates FliA proteolysis
    Title: Cellular levels and activity of the flagellar sigma factor FliA of Escherichia coli are controlled by FlgM-modulated proteolysis.
  2. A complex of E. coli flagellar and chemotaxis-specific sigma factor 28 bound to the 28-binding region of its antisigma factor FlgM has been crystallized.
    Title: Preparation and preliminary X-ray diffraction analysis of crystals of bacterial flagellar sigma factor sigma 28 in complex with the sigma 28-binding region of its antisigma factor, FlgM.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sigma factor antagonist activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
anti-sigma factor for FliA (sigma(28))

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1129835..1130128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415589.1 anti-sigma factor for FliA (sigma(28))

    See identical proteins and their annotated locations for NP_415589.1

    Status: REVIEWED

    Conserved Domains (1) summary
    PRK10810
    Location:1 → 97
    PRK10810; anti-sigma-28 factor FlgM
Nucleotide Protein
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