U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

nfo [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946669, updated on 11-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
nfo
Primary source
ECOCYC:EG10651
Locus tag
b2159
See related
ASAP:ABE-0007146
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2152
Summary
Damaged bases in DNA occur due to alkylating agents, ionizing radiation or oxidants such as superoxide radicals, hydrogen peroxide and hydroxyl radicals. [More information is available at EcoCyc: EG10651].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (2250840..2251697)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional regulator YeiE Neighboring gene PF03601 family inner membrane protein YeiH Neighboring gene putative sugar kinase YeiI Neighboring gene putative nucleoside transporter

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Coupling of the nucleotide incision and 3'-->5' exonuclease activities in Escherichia coli endonuclease IV: Structural and genetic evidences. Golan G, et al. Mutat Res, 2010 Mar 1. PMID 19751747
  2. DNA apurinic-apyrimidinic site binding and excision by endonuclease IV. Garcin ED, et al. Nat Struct Mol Biol, 2008 May. PMID 18408731
  3. Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease IV. Ivanov I, et al. Proc Natl Acad Sci U S A, 2007 Jan 30. PMID 17242363, Free PMC Article
  4. Uncoupling of the base excision and nucleotide incision repair pathways reveals their respective biological roles. Ishchenko AA, et al. Proc Natl Acad Sci U S A, 2006 Feb 21. PMID 16473948, Free PMC Article
  5. Characterization of an endonuclease IV 3'-5' exonuclease activity. Kerins SM, et al. J Biol Chem, 2003 Jan 31. PMID 12444080

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Biochemical, mutational & crystallographic characterization reveal a 3-metal ion mechanism for damage binding and incision; DNA-free and DNA-substrate complex structures capture substrate stabilization by Arg37 and show a distorted Zn3 ligand arrangement.
    Title: DNA apurinic-apyrimidinic site binding and excision by endonuclease IV.
  2. Novel Nfo substrates alpha-2'-deoxyadenosine and alpha-thymidine play an important role in counteracting oxidative DNA base damage.
    Title: Alpha-anomeric deoxynucleotides, anoxic products of ionizing radiation, are substrates for the endonuclease IV-type AP endonucleases.
  3. Endonuclease IV and Exonuclease III have roles in counteracting DNA damage induced by the oxidative counterpart of UVB in E.coli
    Title: Endonuclease IV and exonuclease III are involved in the repair and mutagenesis of DNA lesions induced by UVB in Escherichia coli.
  4. analysis of the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease IV
    Title: Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease IV.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3'-5'-DNA exonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables deoxyribonuclease IV (phage-T4-induced) activity IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoric diester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoric diester hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within base-excision repair TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IC
Inferred by Curator
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
endonuclease IV

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2250840..2251697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416664.1 endonuclease IV [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416664.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6C9Q7X6
    Conserved Domains (1) summary
    PRK01060
    Location:1 → 282
    PRK01060; endonuclease IV; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.