U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

lysP lysine:H(+) symporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946667, updated on 30-Jul-2025
Official Symbol
lysP
Official Full Name
lysine:H(+) symporter
Primary source
ECOCYC:EG11337
Locus tag
b2156
See related
ASAP:ABE-0007131
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
cadR; ECK2149
Summary
LysP is a negative regulator of cadBA expression in the absence of lysine. [More information is available at EcoGene: EG11337]. LysP is one of two principal systems responsible for the uptake of lysine, the other is the ArgT ABC transporter. [More information is available at EcoCyc: EG11337].
Try the new Gene page
Try the new Transcripts and proteins table
Sequence:
NC_000913.3 (2247063..2248532, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene S-formylglutathione hydrolase/S-lactoylglutathione hydrolase Neighboring gene Fe-catecholate outer membrane transporter CirA Neighboring gene DNA-binding transcriptional dual regulator YeiE Neighboring gene PF03601 family inner membrane protein YeiH

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Topological analysis of the lysine-specific permease of Escherichia coli. Ellis J, et al. Microbiology (Reading), 1995 Aug. PMID 7551055
  2. Escherichia coli regulatory mutation affecting lysine transport and lysine decarboxylase. Popkin PS, et al. J Bacteriol, 1980 Feb. PMID 6767681, Free PMC Article
  3. Increase in the rate of L-pipecolic acid production using lat-expressing Escherichia coli by lysP and yeiE amplification. Fujii T, et al. Biosci Biotechnol Biochem, 2002 Sep. PMID 12400704
  4. Construction of an Escherichia coli strain unable to synthesize putrescine, spermidine, or cadaverine: characterization of two genes controlling lysine decarboxylase. Tabor H, et al. J Bacteriol, 1980 Dec. PMID 7002915, Free PMC Article
  5. Sequence analysis of TnphoA insertion sites in Vibrio cholerae mutants defective in rugose polysaccharide production. Ali A, et al. Infect Immun, 2000 Dec. PMID 11083805, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upon induction, lysine-dependent conformational changes in LysP transduce the lysine signal via a direct conformational coupling to CadC without resolving the interaction completely.
    Title: New insights into the interplay between the lysine transporter LysP and the pH sensor CadC in Escherichia coli.
  2. These results indicate that ArgP is a major regulator of lysP expression but that Lrp modulates lysP transcription under lysine-limiting conditions.
    Title: Identification of ArgP and Lrp as transcriptional regulators of lysP, the gene encoding the specific lysine permease of Escherichia coli.
  3. The results suggest a model according to which CadC is inactivated by an interaction with LysP at a low external lysine concentration.
    Title: The membrane-integrated transcriptional activator CadC of Escherichia coli senses lysine indirectly via the interaction with the lysine permease LysP.
  4. N-terminus verified by Edman degradation on mature peptide
    Title: Topological analysis of the lysine-specific permease of Escherichia coli.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-lysine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within L-lysine import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to amino acid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
Preferred Names
lysine:H(+) symporter

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2247063..2248532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416661.1 lysine:H(+) symporter

    See identical proteins and their annotated locations for NP_416661.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A478LCZ7
    Conserved Domains (1) summary
    PRK10836
    Location:1 → 489
    PRK10836; lysine transporter; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.