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cdd cytidine/deoxycytidine deaminase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946663, updated on 19-Nov-2025
Official Symbol
cdd
Official Full Name
cytidine/deoxycytidine deaminase
Primary source
ECOCYC:EG10137
Locus tag
b2143
See related
ASAP:ABE-0007086
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2136
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Sequence:
NC_000913.3 (2231844..2232728)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-dihydrouridine(16) synthase Neighboring gene putative 3-hydroxypropanoate export protein YohJ Neighboring gene putative 3-hydroxypropanoate export protein YohK Neighboring gene DUF218 domain-containing protein SanA Neighboring gene DUF2542 domain-containing protein YeiS

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Cytidine deaminase from Escherichia coli. Purification, properties and inhibition by the potential transition state analog 3,4,5,6-tetrahydrouridine. Cohen RM, et al. J Biol Chem, 1971 Dec 25. PMID 4944311
  2. Major contribution of a carboxymethyl group to transition-state stabilization by cytidine deaminase: mutation and rescue. Carlow DC, et al. Biochemistry, 1995 Apr 4. PMID 7703234
  3. Cytidine deaminase. The 2.3 A crystal structure of an enzyme: transition-state analog complex. Betts L, et al. J Mol Biol, 1994 Jan 14. PMID 8289286
  4. Fusion of the lac genes to the promotor for the cytidine deaminase gene of Escherichia coli K-12. Josephsen J, et al. Mol Gen Genet, 1981. PMID 6455590
  5. Cytidine deaminase complexed to 3-deazacytidine: a "valence buffer" in zinc enzyme catalysis. Xiang S, et al. Biochemistry, 1996 Feb 6. PMID 8634261

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Identifying proteins from two-dimensional gels by molecular mass searching of peptide fragments in protein sequence databases.
  2. examined a transition-state analogue complex formed by Escherichia coli cytidine deaminase by Fourier transform ion cyclotron resonance MS in electrospray mode
    Title: Fourier transform ion cyclotron resonance MS reveals the presence of a water molecule in an enzyme transition-state analogue complex.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables cytidine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytidine deaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cytidine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables cytidine deaminase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables pyrimidine nucleoside binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within deoxycytidine catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within nucleobase-containing small molecule interconversion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyrimidine nucleoside catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
cytidine/deoxycytidine deaminase
NP_416648.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2231844..2232728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416648.1 cytidine/deoxycytidine deaminase

    See identical proteins and their annotated locations for NP_416648.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376U6Z7
    Conserved Domains (1) summary
    PRK09027
    Location:1 → 294
    PRK09027; cytidine deaminase; Provisional
Nucleotide Protein
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Gene LinkOut

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