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mrp [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946627, updated on 24-Aug-2024

Summary

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Official Symbol
mrp
Primary source
ASAP:ABE-0006987
Locus tag
b2113
See related
ECOCYC:EG10611
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2106
Summary
A Salmonella typhimurium apbC mutant exhibits a defect in the alternative pyrimidine biosynthetic pathway, and AbpC is proposed to act in formation of 4-amino-5-hydroxymethyl-2-methyl pyrimidine from aminoimidazole ribonucleotide during thiamine biosynthesis in Salmonella typhimurium . [More information is available at EcoCyc: EG10611].
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Genomic context

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Sequence:
NC_000913.3 (2193059..2194168, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative fimbrial protein YehD Neighboring gene DUF2574 domain-containing protein YehE Neighboring gene methionine--tRNA ligase Neighboring gene PF05406 family protein YehF

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bacterial ApbC protein has two biochemical activities that are required for in vivo function. Boyd JM, et al. J Biol Chem, 2009 Jan 2. PMID 19001370, Free PMC Article
  2. Bacterial ApbC can bind and effectively transfer iron-sulfur clusters. Boyd JM, et al. Biochemistry, 2008 Aug 5. PMID 18616280, Free PMC Article
  3. The Mrp Na+/H+ antiporter increases the activity of the malate:quinone oxidoreductase of an Escherichia coli respiratory mutant. Swartz TH, et al. J Bacteriol, 2005 Jan. PMID 15601724, Free PMC Article
  4. The identification a novel gene required for lipopolysaccharide biosynthesis by Haemophilus influenzae RM7004, using transposon Tn916 mutagenesis. High NJ, et al. FEMS Microbiol Lett, 1996 Dec 15. PMID 8978086
  5. Mutations in apbC (mrp) prevent function of the alternative pyrimidine biosynthetic pathway in Salmonella typhimurium. Petersen L, et al. J Bacteriol, 1996 Oct. PMID 8824612, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent FeS chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron-sulfur cluster assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
P-loop NTPase family protein Mrp

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2193059..2194168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416616.4 P-loop NTPase family protein Mrp [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416616.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AIJ0, A0A8S7EDY9
    Conserved Domains (1) summary
    PRK11670
    Location:1 → 369
    PRK11670; iron-sulfur cluster carrier protein ApbC
Nucleotide Protein
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