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ccmH holocytochrome c synthase CcmH component [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946623, updated on 25-Jun-2025
Official Symbol
ccmH
Official Full Name
holocytochrome c synthase CcmH component
Primary source
ECOCYC:EG12052
Locus tag
b2194
See related
ASAP:ABE-0007262
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2186; yejP
Summary
CcmH is a membrane protein component of the CcmEFGH holocytochrome c synthetase. [More information is available at EcoCyc: EG12052].
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Sequence:
NC_000913.3 (2291358..2292410, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene IS5 family transposase and trans-activator Neighboring gene DNA-binding transcriptional dual regulator NarP Neighboring gene thiol:disulfide oxidoreductase CcmG Neighboring gene holocytochrome c synthase CcmF component Neighboring gene periplasmic heme chaperone Neighboring gene cytochrome c maturation protein D Neighboring gene cytochrome c maturation protein C

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Dispensable residues in the active site of the cytochrome c biogenesis protein CcmH. Robertson IB, et al. FEBS Lett, 2008 Sep 3. PMID 18687332
  2. Helix swapping leads to dimerization of the N-terminal domain of the c-type cytochrome maturation protein CcmH from Escherichia coli. Ahuja U, et al. FEBS Lett, 2008 Aug 6. PMID 18625227
  3. Biochemical properties and catalytic domain structure of the CcmH protein from Escherichia coli. Zheng XM, et al. Biochim Biophys Acta, 2012 Dec. PMID 22789558
  4. A variant System I for cytochrome c biogenesis in archaea and some bacteria has a novel CcmE and no CcmH. Allen JW, et al. FEBS Lett, 2006 Sep 4. PMID 16920107
  5. Functional characterization of the C-terminal domain of the cytochrome c maturation protein CcmE. Harvat EM, et al. J Biol Chem, 2005 Nov 4. PMID 16129669

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mature CcmH is a periplasm-resident oxidoreductase anchored to the inner membrane by two transmembrane segments
    Title: Biochemical properties and catalytic domain structure of the CcmH protein from Escherichia coli.
  2. The active-site cysteines of E. coli CcmH, as well as R42, S54, R63, were replaced with alanine and the replacement effect on cytochrome c production was tested.
    Title: Dispensable residues in the active site of the cytochrome c biogenesis protein CcmH.
  3. CcmH forms a tightly interlinked dimer by swapping its N-terminal helix between two monomers.
    Title: Helix swapping leads to dimerization of the N-terminal domain of the c-type cytochrome maturation protein CcmH from Escherichia coli.
  4. Data show that a variant System I for cytochrome c biogenesis in archaea and some bacteria has a novel CcmE and no CcmH.
    Title: A variant System I for cytochrome c biogenesis in archaea and some bacteria has a novel CcmE and no CcmH.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-disulfide reductase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytochrome complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cytochrome complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
holocytochrome c synthase CcmH component

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2291358..2292410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416698.1 holocytochrome c synthase CcmH component [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416698.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5N3D656, A0A6D0IAV7, A0A8T5ZUP0
    Conserved Domains (3) summary
    COG3088
    Location:1 → 133
    NrfF; Cytochrome c-type biogenesis protein CcmH/NrfF [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
    COG4235
    Location:136 → 350
    NrfG; Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:222 → 250
    TPR; TPR repeat [structural motif]
Nucleotide Protein
Heading Accession and Version

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