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gyrA DNA gyrase subunit A [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946614, updated on 11-Oct-2018

Summary

Gene symbol
gyrA
Gene description
DNA gyrase subunit A
Primary source
EcoGene:EG10423
Locus tag
b2231
See related
ASAP:ABE-0007370; ECOCYC:EG10423
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2223; hisW; nalA; nfxA; norA; parD
Summary
gyrA is an essential gene. [More information is available at EcoGene: EG10423]. DNA gyrase is one of two essential members of the type II topoisomerase family in Escherichia coli. [More information is available at EcoCyc: EG10423].

Genomic context

Sequence:
NC_000913.3 (2336793..2339420, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene DUF1175 domain-containing protein YfaT Neighboring gene DUF2138 domain-containing protein YfaA Neighboring gene bifunctional 3-demethylubiquinone-8 3-O-methyltransferase and 2-octaprenyl-6-hydroxyphenol methylase Neighboring gene putative autotransporter adhesin YfaL

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA supercoiling activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to DNA topoisomerase type II (ATP-hydrolyzing) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topoisomerase type II (ATP-hydrolyzing) activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-dependent ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA topological change IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA topological change IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to drug IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
DNA topoisomerase complex (ATP-hydrolyzing) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA gyrase subunit A
NP_416734.1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2336793..2339420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416734.1 DNA gyrase subunit A [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416734.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P0AES4
    Conserved Domains (2) summary
    PRK05560
    Location:7842
    PRK05560; DNA gyrase subunit A; Validated
    sd00041
    Location:538585
    GyrA-ParC_C; GyrA_CTD repeat [structural motif]
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