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baeS sensor histidine kinase BaeS [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946611, updated on 26-Mar-2025

Summary

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Official Symbol
baeS
Official Full Name
sensor histidine kinase BaeS
Primary source
ECOCYC:EG11617
Locus tag
b2078
See related
ASAP:ABE-0006882
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2074
Summary
Confers novobiocin and deoxycholate resistance via activation of mdtABCD and acrD transcription. [More information is available at EcoGene: EG11617]. BaeS is the sensor kinase protein of the two-component BaeSR signal transduction system . [More information is available at EcoCyc: EG11617].
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Genomic context

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Sequence:
NC_000913.3 (2162876..2164279)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene multidrug efflux pump membrane fusion protein MdtA Neighboring gene multidrug efflux pump RND permease subunit MdtB Neighboring gene multidrug efflux pump RND permease subunit MdtC Neighboring gene putative multidrug efflux pump MdtD Neighboring gene DNA-binding transcriptional activator BaeR Neighboring gene DUF1508 domain-containing protein YegP Neighboring gene tRNA wobble base hydroxylation protein TrhP

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the induction and cellular role of the BaeSR two-component envelope stress response of Escherichia coli. Leblanc SK, et al. J Bacteriol, 2011 Jul. PMID 21515766, Free PMC Article
  2. BaeSR activates type VI secretion system expression in porcine extra-intestinal pathogenic Escherichia coli to enhance bacterial resistance to zinc stress. Hu L, et al. Microb Pathog, 2020 Oct. PMID 32603765
  3. The BaeSR two-component regulatory system mediates resistance to condensed tannins in Escherichia coli. Zoetendal EG, et al. Appl Environ Microbiol, 2008 Jan. PMID 18039828, Free PMC Article
  4. Involvement of multiple transcription factors for metal-induced spy gene expression in Escherichia coli. Yamamoto K, et al. J Biotechnol, 2008 Jan 20. PMID 17884222
  5. Genome-wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system. Nishino K, et al. J Bacteriol, 2005 Mar. PMID 15716448, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BaeSR activates type VI secretion system expression in porcine extra-intestinal pathogenic Escherichia coli to enhance bacterial resistance to zinc stress.
    Title: BaeSR activates type VI secretion system expression in porcine extra-intestinal pathogenic Escherichia coli to enhance bacterial resistance to zinc stress.
  2. The authors hypothesize that the main function of the BaeSR-mediated response is to upregulate efflux pump expression in response to specific envelope-damaging agents.
    Title: Characterization of the induction and cellular role of the BaeSR two-component envelope stress response of Escherichia coli.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphorelay sensor kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphorelay sensor kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein histidine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to cell envelope stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphorelay signal transduction system IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
sensor histidine kinase BaeS
NP_416582.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2162876..2164279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416582.1 sensor histidine kinase BaeS [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416582.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T5YF02
    Conserved Domains (1) summary
    PRK10549
    Location:1 → 467
    PRK10549; two-component system sensor histidine kinase BaeS
Nucleotide Protein
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