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mdtA [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946604, updated on 11-Sep-2024

Summary

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Official Symbol
mdtA
Primary source
ECOCYC:G7113
Locus tag
b2074
See related
ASAP:ABE-0006872
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2070; yegM
Summary
mdtABC overexpression confers resistance to deoxycholate and novobiocin. [More information is available at EcoGene: EG14056]. [More information is available at EcoCyc: G7113].
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Genomic context

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Sequence:
NC_000913.3 (2154016..2155263)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene toxic peptide IbsA Neighboring gene ncRNA Neighboring gene putative toxic peptide IbsB Neighboring gene multidrug efflux pump RND permease subunit MdtB Neighboring gene multidrug efflux pump RND permease subunit MdtC

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multidrug efflux pump MdtBC of Escherichia coli is active only as a B2C heterotrimer. Kim HS, et al. J Bacteriol, 2010 Mar. PMID 20038594, Free PMC Article
  2. AcrB, AcrD, and MdtABC multidrug efflux systems are involved in enterobactin export in Escherichia coli. Horiyama T, et al. PLoS One, 2014. PMID 25259870, Free PMC Article
  3. The baeSR two-component regulatory system activates transcription of the yegMNOB (mdtABCD) transporter gene cluster in Escherichia coli and increases its resistance to novobiocin and deoxycholate. Baranova N, et al. J Bacteriol, 2002 Aug. PMID 12107134, Free PMC Article
  4. Indole induces the expression of multidrug exporter genes in Escherichia coli. Hirakawa H, et al. Mol Microbiol, 2005 Feb. PMID 15686558
  5. Beta-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli. Hirakawa H, et al. J Antimicrob Chemother, 2003 Oct. PMID 12951338

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables bile acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables efflux transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within bile acid and bile salt transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic detoxification by transmembrane export across the cell outer membrane NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within xenobiotic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of efflux pump complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of efflux pump complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in periplasmic side of plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
multidrug efflux pump membrane fusion protein MdtA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2154016..2155263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416578.2 multidrug efflux pump membrane fusion protein MdtA [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416578.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7FD40
    Conserved Domains (1) summary
    PRK11556
    Location:1 → 415
    PRK11556; MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit
Nucleotide Protein
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