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dgcE diguanylate cyclase DgcE [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946600, updated on 19-Nov-2025
Official Symbol
dgcE
Official Full Name
diguanylate cyclase DgcE
Primary source
ECOCYC:EG12396
Locus tag
b2067
See related
ASAP:ABE-0006845
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2061; yegE
Summary
A yegE null mutation partially suppresses the motility defect of a yhjH mutation; yegE partial suppression is best at 28C, full yhjH suppression requires yegE and yedQ mutations; a yeaJ null mutation is a better yhjH suppressor at 37C; full yhjH suppression requires yegE, yedQ and yeaJ null mutations when grown at 37C (Pesavento, 2008). [More information is available at EcoGene: EG12396]. YegE is a GGDEF/EAL protein that is involved in regulation of the switch from flagellar motility to sessile behavior and curli expression . [More information is available at EcoCyc: EG12396].
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Sequence:
NC_000913.3 (2143266..2146583)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene dCTP deaminase Neighboring gene uridine/cytidine kinase Neighboring gene DNA-3-methyladenine glycosylase 2 Neighboring gene HSP70 family protein YegD

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. More than Enzymes That Make or Break Cyclic Di-GMP-Local Signaling in the Interactome of GGDEF/EAL Domain Proteins of Escherichia coli. Sarenko O, et al. mBio, 2017 Oct 10. PMID 29018125, Free PMC Article
  2. Structure and expression of the alkA gene of Escherichia coli involved in adaptive response to alkylating agents. Nakabeppu Y, et al. J Biol Chem, 1984 Nov 25. PMID 6094528
  3. A comprehensive genetic characterization of bacterial motility. Girgis HS, et al. PLoS Genet, 2007 Sep. PMID 17941710, Free PMC Article
  4. Second messenger-mediated adjustment of bacterial swimming velocity. Boehm A, et al. Cell, 2010 Apr 2. PMID 20303158
  5. Gene expression patterns and differential input into curli fimbriae regulation of all GGDEF/EAL domain proteins in Escherichia coli. Sommerfeldt N, et al. Microbiology (Reading), 2009 Apr. PMID 19332833

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables diguanylate cyclase activity EXP
Inferred from Experiment
more info
 PubMed 
enables diguanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diguanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of single-species biofilm formation on inanimate substrate IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
diguanylate cyclase DgcE
NP_416571.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2143266..2146583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416571.1 diguanylate cyclase DgcE

    See identical proteins and their annotated locations for NP_416571.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A779QBG9
    Conserved Domains (1) summary
    PRK09776
    Location:20 → 1105
    PRK09776; putative diguanylate cyclase; Provisional
Nucleotide Protein
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