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rutE putative malonic semialdehyde reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946591, updated on 3-Dec-2024

Summary

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Official Symbol
rutE
Official Full Name
putative malonic semialdehyde reductase
Primary source
ECOCYC:G6519
Locus tag
b1008
See related
ASAP:ABE-0003407
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0999; ycdI
Summary
Escherichia coli K-12 contains a previously undescribed pathway for pyrimidine degradation. [More information is available at EcoCyc: G6519].
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Genomic context

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Sequence:
NC_000913.3 (1070365..1070955, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pyrimidine:H(+) symporter Neighboring gene FMN reductase RutF Neighboring gene putative aminoacrylate hydrolase RutD Neighboring gene 3-aminoacrylate deaminase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954. Prosser GA, et al. Biochem Pharmacol, 2010 Mar 1. PMID 19852945
  2. Comparative genomics reveals novel biochemical pathways. Piskur J, et al. Trends Genet, 2007 Aug. PMID 17555842
  3. A hidden metabolic pathway exposed. Osterman A. Proc Natl Acad Sci U S A, 2006 Apr 11. PMID 16595627, Free PMC Article
  4. The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems. Kim KS, et al. J Bacteriol, 2010 Aug. PMID 20400551, Free PMC Article
  5. Nitrogen regulatory protein C-controlled genes of Escherichia coli: scavenging as a defense against nitrogen limitation. Zimmer DP, et al. Proc Natl Acad Sci U S A, 2000 Dec 19. PMID 11121068, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-hydroxypropionate dehydrogenase (NADP+) activity EXP
Inferred from Experiment
more info
 PubMed 
enables 3-hydroxypropionate dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables FMN binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in nitrogen utilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nitrogen utilization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nitrogen utilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within pyrimidine nucleobase catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in uracil catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in uracil catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within uracil catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
putative malonic semialdehyde reductase
NP_415528.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1070365..1070955 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415528.1 putative malonic semialdehyde reductase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415528.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T6BX66
    Conserved Domains (1) summary
    PRK05365
    Location:2 → 196
    PRK05365; malonic semialdehyde reductase; Provisional
Nucleotide Protein
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