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rutG pyrimidine:H(+) symporter [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946589, updated on 26-Mar-2025
Official Symbol
rutG
Official Full Name
pyrimidine:H(+) symporter
Primary source
ECOCYC:G6517
Locus tag
b1006
See related
ASAP:ABE-0003401
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0997; ycdG
Summary
NtrC regulon. [More information is available at EcoGene: EG13853]. Escherichia coli K-12 contains a previously undescribed pathway for pyrimidine degradation. [More information is available at EcoCyc: G6517].
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Sequence:
NC_000913.3 (1068511..1069839, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene NAD(P)H:quinone oxidoreductase Neighboring gene stress-induced bacterial acidophilic repeat motifs-containing protein YmdF Neighboring gene FMN reductase RutF Neighboring gene putative malonic semialdehyde reductase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Insight on specificity of uracil permeases of the NAT/NCS2 family from analysis of the transporter encoded in the pyrimidine utilization operon of Escherichia coli. Botou M, et al. Mol Microbiol, 2018 Apr. PMID 29437264
  2. Comparative genomics reveals novel biochemical pathways. Piskur J, et al. Trends Genet, 2007 Aug. PMID 17555842
  3. A hidden metabolic pathway exposed. Osterman A. Proc Natl Acad Sci U S A, 2006 Apr 11. PMID 16595627, Free PMC Article
  4. The Rut pathway for pyrimidine degradation: novel chemistry and toxicity problems. Kim KS, et al. J Bacteriol, 2010 Aug. PMID 20400551, Free PMC Article
  5. Nitrogen regulatory protein C-controlled genes of Escherichia coli: scavenging as a defense against nitrogen limitation. Zimmer DP, et al. Proc Natl Acad Sci U S A, 2000 Dec 19. PMID 11121068, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RutG is a high-affinity permease for uracil, thymine and, at low efficiency, xanthine and recognizes also 5-fluorouracil and oxypurinol.
    Title: Insight on specificity of uracil permeases of the NAT/NCS2 family from analysis of the transporter encoded in the pyrimidine utilization operon of Escherichia coli.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables nucleobase transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables pyrimidine nucleobase transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyrimidine nucleotide transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables uracil transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables uracil:monoatomic cation symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables uracil:monoatomic cation symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within pyrimidine nucleobase transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyrimidine nucleotide transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within uracil catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in uracil import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within uracil import across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within uracil import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Preferred Names
pyrimidine:H(+) symporter

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1068511..1069839 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415526.4 pyrimidine:H(+) symporter [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415526.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8T6PPA9
    Conserved Domains (1) summary
    TIGR03616
    Location:1 → 429
    RutG; pyrimidine utilization transport protein G
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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