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wzc protein-tyrosine kinase Wzc [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946567, updated on 25-Jun-2025
Official Symbol
wzc
Official Full Name
protein-tyrosine kinase Wzc
Primary source
ECOCYC:G7105
Locus tag
b2060
See related
ASAP:ABE-0006819
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2054
Summary
Wzc, but not Wzc-P, activates colanic acid synthesis, needed for capsule production. [More information is available at EcoGene: EG13568]. Wzc catalyzes autophosphorylation on tyrosine . [More information is available at EcoCyc: G7105].
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Sequence:
NC_000913.3 (2133490..2135652, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene colanic acid biosynthesis galactosyltransferase WcaC Neighboring gene colanic acid biosynthesis acetyltransferase WcaB Neighboring gene UDP-glucuronate:2-O-Ac-beta-D-Gal-(1->3)-alpha-L-Fuc-(1->4)-2/3-O-Ac-alpha-L-Fuc-(1->3)-beta-D-Glc-PP-Und beta-(1,3)-glucuronosyltransferase Neighboring gene protein-tyrosine phosphatase Neighboring gene outer membrane polysaccharide export protein Wza

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Identification of structural and molecular determinants of the tyrosine-kinase Wzc and implications in capsular polysaccharide export. Bechet E, et al. Mol Microbiol, 2010 Sep. PMID 20633230
  2. The molecular basis of regulation of bacterial capsule assembly by Wzc. Yang Y, et al. Nat Commun, 2021 Jul 16. PMID 34272394, Free PMC Article
  3. Phosphorylation of the integrase protein of coliphage HK022. Kolot M, et al. Virology, 2008 Jun 5. PMID 18353423
  4. Tyrosine-kinase Wzc from Escherichia coli possesses an ATPase activity regulated by autophosphorylation. Soulat D, et al. FEMS Microbiol Lett, 2007 Sep. PMID 17627778
  5. Periplasmic protein-protein contacts in the inner membrane protein Wzc form a tetrameric complex required for the assembly of Escherichia coli group 1 capsules. Collins RF, et al. J Biol Chem, 2006 Jan 27. PMID 16172129, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The molecular basis of regulation of bacterial capsule assembly by Wzc.
    Title: The molecular basis of regulation of bacterial capsule assembly by Wzc.
  2. Mutational analysis demonstrates that a conserved EX(2) RX(2) R motif involved in subunit interactions is essential for polysaccharide export.
    Title: Identification of structural and molecular determinants of the tyrosine-kinase Wzc and implications in capsular polysaccharide export.
  3. Wzc protein-protein contacts form a tetrameric complex required for the assembly of Escherichia coli group 1 capsules
    Title: Periplasmic protein-protein contacts in the inner membrane protein Wzc form a tetrameric complex required for the assembly of Escherichia coli group 1 capsules.
  4. the Wza-Wzc complex provides the structural and regulatory core of a larger macromolecular machine, suggesting a mechanism by which capsular polysaccharides may move from the periplasm through the outer membrane
    Title: The 3D structure of a periplasm-spanning platform required for assembly of group 1 capsular polysaccharides in Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within colanic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 
Preferred Names
protein-tyrosine kinase Wzc

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2133490..2135652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416564.4 protein-tyrosine kinase Wzc [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416564.4

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    G1UG17
    Conserved Domains (1) summary
    PRK11519
    Location:1 → 719
    PRK11519; tyrosine-protein kinase Wzc
Nucleotide Protein
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