U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

wzb [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946564, updated on 11-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
wzb
Primary source
ECOCYC:G7106
Locus tag
b2061
See related
ASAP:ABE-0006822
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2055
Summary
Dephosphorylates Wzc-P in vitro and in vivo. [More information is available at EcoGene: EG13567]. Wzb is a tyrosine phosphatase . [More information is available at EcoCyc: G7106].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (2135655..2136098, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene UDP-glucuronate:2-O-Ac-beta-D-Gal-(1->3)-alpha-L-Fuc-(1->4)-2/3-O-Ac-alpha-L-Fuc-(1->3)-beta-D-Glc-PP-Und beta-(1,3)-glucuronosyltransferase Neighboring gene protein-tyrosine kinase Wzc Neighboring gene outer membrane polysaccharide export protein Wza Neighboring gene inner membrane protein YegH

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Crystallization and preliminary crystallographic analysis of the bacterial capsule assembly-regulating tyrosine phosphatases Wzb of Escherichia coli and Cps4B of Streptococcus pneumoniae. Huang H, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009 Aug 1. PMID 19652335, Free PMC Article
  2. The solution structure of Escherichia coli Wzb reveals a novel substrate recognition mechanism of prokaryotic low molecular weight protein-tyrosine phosphatases. Lescop E, et al. J Biol Chem, 2006 Jul 14. PMID 16651264
  3. functional analysis of conserved gene products involved in assembly of Escherichia coli capsules and exopolysaccharides: evidence for molecular recognition between Wza and Wzc for colanic acid biosynthesis. Reid AN, et al. J Bacteriol, 2005 Aug. PMID 16030241, Free PMC Article
  4. Tyrosine phosphorylation of protein kinase Wzc from Escherichia coli K12 occurs through a two-step process. Grangeasse C, et al. J Biol Chem, 2002 Mar 1. PMID 11751920
  5. Escherichia coli RcsA, a positive activator of colanic acid capsular polysaccharide synthesis, functions To activate its own expression. Ebel W, et al. J Bacteriol, 1999 Jan. PMID 9882673, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results present the structure of Wzb in complex with phosphate and high-resolution structures of apo-CpsB and a phosphate-complexed CpsB.
    Title: Crystal structures of Wzb of Escherichia coli and CpsB of Streptococcus pneumoniae, representatives of two families of tyrosine phosphatases that regulate capsule assembly.
  2. Escherichia coli Wzb solution structure reveals a novel substrate recognition mechanism of prokaryotic low molecular weight protein-tyrosine phosphatases
    Title: The solution structure of Escherichia coli Wzb reveals a novel substrate recognition mechanism of prokaryotic low molecular weight protein-tyrosine phosphatases.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within colanic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein-tyrosine phosphatase
NP_416565.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2135655..2136098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416565.1 protein-tyrosine phosphatase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416565.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A792DKM8
    Conserved Domains (1) summary
    PRK10126
    Location:1 → 147
    PRK10126; low molecular weight protein-tyrosine-phosphatase Wzb
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.