U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

fcl GDP-L-fucose synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946563, updated on 9-Mar-2022

Summary

Gene symbol
fcl
Gene description
GDP-L-fucose synthase
Primary source
ASAP:ABE-0006801
Locus tag
b2052
See related
ECOCYC:EG11788
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2046; wcaG; yefB
Summary
GDP-fucose synthase is a bifunctional enzyme that catalyzes the two-step synthesis of GDP-fucose from GDP-4-dehydro-6-deoxy-D-mannose via a GDP-4-dehydro-6-L-deoxygalactose intermediate . [More information is available at EcoCyc: EG11788].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Sequence:
NC_000913.3 (2126225..2127190, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene mannose-1-phosphate guanylyltransferase Neighboring gene colanic acid biosynthesis fucosyltransferase WcaI Neighboring gene GDP-mannose mannosyl hydrolase Neighboring gene GDP-mannose 4,6-dehydratase Neighboring gene colanic acid biosynthesis acetyltransferase WcaF

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables GDP-L-fucose synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GDP-L-fucose synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GDP-L-fucose synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables NADP+ binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in 'de novo' GDP-L-fucose biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in colanic acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleotide-sugar biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
GDP-L-fucose synthase
NP_416556.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2126225..2127190 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416556.1 GDP-L-fucose synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416556.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P32055
    Conserved Domains (1) summary
    cd05239
    Location:5313
    GDP_FS_SDR_e; GDP-fucose synthetase, extended (e) SDRs