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hisB imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946552, updated on 17-Jul-2025
Official Symbol
hisB
Official Full Name
imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase
Primary source
ECOCYC:EG10445
Locus tag
b2022
See related
ASAP:ABE-0006720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2017
Summary
HAD superfamily. [More information is available at EcoGene: EG10445]. The bifunctional imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (HisB) carries out the sixth and eight steps of histidine biosynthesis. [More information is available at EcoCyc: EG10445].
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Sequence:
NC_000913.3 (2093468..2094535)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ATP phosphoribosyltransferase Neighboring gene histidinal/histidinol dehydrogenase Neighboring gene histidinol-phosphate aminotransferase Neighboring gene imidazole glycerol phosphate synthase subunit HisH Neighboring gene 1-(5-phosphoribosyl)-5- Neighboring gene imidazole glycerol phosphate synthase subunit HisF Neighboring gene putative bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The hisB463 mutation and expression of a eukaryotic protein in Escherichia coli. Struhl K. Genetics, 2008 Oct. PMID 18927256, Free PMC Article
  2. Some properties of the catalytic sites of imidazoleglycerol phosphate dehydratase-histidinol phosphate phosphatase, a bifunctional enzyme from Salmonella typhimurium. Brady DR, et al. J Biol Chem, 1973 Apr 10. PMID 4349042
  3. Divalent metal ion effects on a mutant histidinol phosphate phosphatase from Salmonella typhimurium. Houston LL, et al. Arch Biochem Biophys, 1974 Jun. PMID 4366369
  4. Genetic fusions that place the lactose genes under histidine operon control. Chumley FG, et al. J Mol Biol, 1981 Feb 5. PMID 6267294
  5. Cloning and expression of the distal portion of the histidine operon of Escherichia coli K-12. Grisolia V, et al. J Bacteriol, 1982 Aug. PMID 6284708, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: '98 Escherichia coli SWISS-2DPAGE database update.
  2. The structure shows the presence of a structural Zn(2+) ion stabilizing the conformation of an extended loop. Two metal binding sites were also identified in the active site.
    Title: Structural snapshots of Escherichia coli histidinol phosphate phosphatase along the reaction pathway.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables histidinol-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables imidazoleglycerol-phosphate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables imidazoleglycerol-phosphate dehydratase activity IDA
Inferred from Direct Assay
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-histidine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within L-histidine biosynthetic process IDA
Inferred from Direct Assay
more info
  
Preferred Names
imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase
NP_416526.4

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2093468..2094535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416526.4 imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase

    See identical proteins and their annotated locations for NP_416526.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    C3SD47
    Conserved Domains (1) summary
    PRK05446
    Location:2 → 355
    PRK05446; bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB
Nucleotide Protein
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Gene LinkOut

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