U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

hisC histidinol-phosphate aminotransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946551, updated on 30-Jul-2025
Official Symbol
hisC
Official Full Name
histidinol-phosphate aminotransferase
Primary source
ECOCYC:EG10446
Locus tag
b2021
See related
ASAP:ABE-0006717
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2016
Summary
Histidinol-phosphate aminotransferase (HisC) catalyzes the seventh step in the biosynthesis of histidine. [More information is available at EcoCyc: EG10446].
NEW
Try the new Gene table
Try the new Transcript table
Sequence:
NC_000913.3 (2092398..2093468)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene his operon leader peptide Neighboring gene ATP phosphoribosyltransferase Neighboring gene histidinal/histidinol dehydrogenase Neighboring gene imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase Neighboring gene imidazole glycerol phosphate synthase subunit HisH Neighboring gene 1-(5-phosphoribosyl)-5- Neighboring gene imidazole glycerol phosphate synthase subunit HisF

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Cloning, structure, and expression of the Escherichia coli K-12 hisC gene. Grisolia V, et al. J Bacteriol, 1985 Dec. PMID 2999081, Free PMC Article
  2. Imidazolylacetolphosphate:L-glutamate aminotransferase. Purification and physical properties. Martin RG, et al. J Biol Chem, 1967 Mar 25. PMID 5337155
  3. Characterization of histidinol phosphate aminotransferase from Escherichia coli. Mizuguchi H, et al. Biochim Biophys Acta, 2003 Apr 11. PMID 12686152
  4. Crystal structure of histidinol phosphate aminotransferase (HisC) from Escherichia coli, and its covalent complex with pyridoxal-5'-phosphate and l-histidinol phosphate. Sivaraman J, et al. J Mol Biol, 2001 Aug 24. PMID 11518529
  5. Structures of Escherichia coli histidinol-phosphate aminotransferase and its complexes with histidinol-phosphate and N-(5'-phosphopyridoxyl)-L-glutamate: double substrate recognition of the enzyme. Haruyama K, et al. Biochemistry, 2001 Apr 17. PMID 11294630

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables histidinol-phosphate transaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histidinol-phosphate transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-histidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-histidine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
histidinol-phosphate aminotransferase
NP_416525.1

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2092398..2093468
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416525.1 histidinol-phosphate aminotransferase

    See identical proteins and their annotated locations for NP_416525.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8I0CCU9
    Conserved Domains (1) summary
    PRK01688
    Location:3 → 352
    PRK01688; histidinol-phosphate aminotransferase; Provisional
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.