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sbmC DNA gyrase inhibitor [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946546, updated on 3-Dec-2024
Official Symbol
sbmC
Official Full Name
DNA gyrase inhibitor
Primary source
ECOCYC:EG11892
Locus tag
b2009
See related
ASAP:ABE-0006670
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
dgi; ECK2003; gyrI; yeeB
Summary
sbmC has been demonstrated to to have a CRP-S promoter co-regulated by both Crp and Sxy (Cameron, 2006). [More information is available at EcoGene: EG11892]. SbmC is an inhibitor of DNA gyrase-mediated DNA supercoiling that inhibits the enzyme activity at an early step . [More information is available at EcoCyc: EG11892].
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Sequence:
NC_000913.3 (2080789..2081262, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YoeJ Neighboring gene putative transporter YeeA Neighboring gene D-alanyl-D-alanine carboxypeptidase DacD Neighboring gene exodeoxyribonuclease I

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Chromosomally encoded gyrase inhibitor GyrI protects Escherichia coli against DNA-damaging agents. Chatterji M, et al. Arch Microbiol, 2003 Nov. PMID 13680098
  2. The Escherichia coli SOS gene sbmC is regulated by H-NS and RpoS during the SOS induction and stationary growth phase. Oh TJ, et al. Biochem Biophys Res Commun, 2001 Nov 9. PMID 11689018
  3. [DNA gyrase inhibitor (GyrI) of Escherichia coli]. Nakanishi A, et al. Seikagaku, 1999 Jun. PMID 10432838
  4. sbmC, a stationary-phase induced SOS Escherichia coli gene, whose product protects cells from the DNA replication inhibitor microcin B17. Baquero MR, et al. Mol Microbiol, 1995 Oct. PMID 8709849
  5. Identification of DNA gyrase inhibitor (GyrI) in Escherichia coli. Nakanishi A, et al. J Biol Chem, 1998 Jan 23. PMID 9442027

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Identification of DNA gyrase inhibitor (GyrI) in Escherichia coli.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
DNA gyrase inhibitor

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2080789..2081262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416513.1 DNA gyrase inhibitor [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416513.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAN3IHP9
    Conserved Domains (1) summary
    PRK10016
    Location:1 → 156
    PRK10016; DNA gyrase inhibitor SbmC
Nucleotide Protein
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