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hisH imidazole glycerol phosphate synthase subunit HisH [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946544, updated on 26-Mar-2025
Official Symbol
hisH
Official Full Name
imidazole glycerol phosphate synthase subunit HisH
Primary source
ECOCYC:EG10450
Locus tag
b2023
See related
ASAP:ABE-0006722
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2018
Summary
N-terminus of purified HisH was sequenced by Klem and Davisson (1993), and the fMet is not clipped. [More information is available at EcoGene: EG10450]. Imidazole glycerol phosphate synthase (HisFH) is a heterodimer that carries out the fifth step in histidine biosynthesis, as well as generating aminoimidazole carboxamide ribonucleotide, an intermediate in purine nucleotide biosynthesis. [More information is available at EcoCyc: EG10450].
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Sequence:
NC_000913.3 (2094535..2095125)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ATP phosphoribosyltransferase Neighboring gene histidinal/histidinol dehydrogenase Neighboring gene histidinol-phosphate aminotransferase Neighboring gene imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase Neighboring gene 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase Neighboring gene imidazole glycerol phosphate synthase subunit HisF Neighboring gene putative bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase Neighboring gene O-antigen co-polymerase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. In vivo evaluation of the interaction between the Escherichia coli IGP synthase subunits using the Bacterial Two-Hybrid system. Chioccioli S, et al. FEMS Microbiol Lett, 2020 Jul 1. PMID 32614412
  2. Histidine-requiring mutants of Escherichia coli K12. Garrick-Silversmith L, et al. Genetics, 1970 Oct. PMID 4934198, Free PMC Article
  3. Kinetic model of imidazologlycerol-phosphate synthetase from Escherichia coli. Demin OV, et al. Biochemistry (Mosc), 2004 Dec. PMID 15627387
  4. On the structure of hisH: protein structure prediction in the context of structural and functional genomics. O'Donoghue P, et al. J Struct Biol, 2001 May-Jun. PMID 11551184
  5. Suppression of the pleiotropic effects of HisH and HisF overproduction identifies four novel loci on the Salmonella typhimurium chromosome: osmH, sfiW, sfiX, and sfiY. Flores A, et al. J Bacteriol, 1995 Sep. PMID 7665459, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In vivo evaluation of the interaction between the Escherichia coli IGP synthase subunits using the Bacterial Two-Hybrid system.
    Title: In vivo evaluation of the interaction between the Escherichia coli IGP synthase subunits using the Bacterial Two-Hybrid system.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glutaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables imidazoleglycerol-phosphate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables imidazoleglycerol-phosphate synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables imidazoleglycerol-phosphate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables pentosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within L-histidine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-histidine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in L-histidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of imidazoleglycerol-phosphate synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of imidazoleglycerol-phosphate synthase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
imidazole glycerol phosphate synthase subunit HisH
NP_416527.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2094535..2095125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416527.1 imidazole glycerol phosphate synthase subunit HisH [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416527.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8NJJ9, B1B4V3
    Conserved Domains (1) summary
    PRK13170
    Location:1 → 196
    hisH; imidazole glycerol phosphate synthase subunit HisH; Provisional
Nucleotide Protein
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