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pykA pyruvate kinase 2 [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946527, updated on 23-Nov-2023

Summary

Gene symbol
pykA
Gene description
pyruvate kinase 2
Primary source
ASAP:ABE-0006182
Locus tag
b1854
See related
ECOCYC:EG10803
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1855
Summary
PykA contributes significantly less than PykF to in vivo pyruvate kinase activity (Ponce, 1995; Al Zaid Siddiquee, 2004). [More information is available at EcoGene: EG10803]. [More information is available at EcoCyc: EG10803].
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Genomic context

Sequence:
NC_000913.3 (1937649..1939091)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene NADP(+)-dependent glucose-6-phosphate dehydrogenase Neighboring gene DNA-binding transcriptional repressor YebK Neighboring gene Lipid A biosynthesis myristoyltransferase Neighboring gene peptidoglycan endopeptidase MepM

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables AMP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables potassium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables pyruvate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pyruvate kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables pyruvate kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
 
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of pyruvate kinase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pyruvate kinase 2
NP_416368.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1937649..1939091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416368.1 pyruvate kinase 2 [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416368.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AJF4, A0A9P2GK87
    Conserved Domains (1) summary
    PRK05826
    Location:3469
    PRK05826; pyruvate kinase; Provisional