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cobS cobalamin 5'-phosphate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946520, updated on 22-Sep-2022

Summary

Gene symbol
cobS
Gene description
cobalamin 5'-phosphate synthase
Primary source
ASAP:ABE-0006613
Locus tag
b1992
See related
ECOCYC:EG12150
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1987
Summary
Escherichia coli K-12, as well as natural isolates, can synthesize cobalamin only when supplied with the intermediate cobinamide . cobS encodes a predicted cobalamin synthase . [More information is available at EcoCyc: EG12150].
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Genomic context

Sequence:
NC_000913.3 (2064479..2065222, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene L,D-transpeptidase LdtA Neighboring gene nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Neighboring gene cobinamide-P guanylyltransferase/cobinamide kinase Neighboring gene pseudo Neighboring gene IS5 family transposase and trans-activator

Pathways from PubChem

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables adenosylcobinamide-GDP ribazoletransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables adenosylcobinamide-GDP ribazoletransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables adenosylcobinamide-GDP ribazoletransferase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables cobalamin 5'-phosphate synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cobalamin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cobalamin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cobalamin biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cobalamin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cobalamin 5'-phosphate synthase
NP_416496.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2064479..2065222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416496.1 cobalamin 5'-phosphate synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416496.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P36561
    Conserved Domains (1) summary
    TIGR00317
    Location:1246
    cobS; cobalamin 5'-phosphate synthase/cobalamin synthase