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cobS cobalamin 5'-phosphate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946520, updated on 19-Nov-2025
Official Symbol
cobS
Official Full Name
cobalamin 5'-phosphate synthase
Primary source
ECOCYC:EG12150
Locus tag
b1992
See related
ASAP:ABE-0006613
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1987
Summary
Escherichia coli K-12, as well as natural isolates, can synthesize cobalamin only when supplied with the intermediate cobinamide . cobS encodes a predicted cobalamin synthase . [More information is available at EcoCyc: EG12150].
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Sequence:
NC_000913.3 (2064479..2065222, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene L,D-transpeptidase LdtA Neighboring gene nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase Neighboring gene cobinamide-P guanylyltransferase/cobinamide kinase Neighboring gene pseudo Neighboring gene IS5 transposase and trans-activator

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Evolution of coenzyme B12 synthesis among enteric bacteria: evidence for loss and reacquisition of a multigene complex. Lawrence JG, et al. Genetics, 1996 Jan. PMID 8770581, Free PMC Article
  2. A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map. Itoh T, et al. DNA Res, 1996 Dec 31. PMID 9097040
  3. The cobalamin (coenzyme B12) biosynthetic genes of Escherichia coli. Lawrence JG, et al. J Bacteriol, 1995 Nov. PMID 7592411, Free PMC Article
  4. Global topology analysis of the Escherichia coli inner membrane proteome. Daley DO, et al. Science, 2005 May 27. PMID 15919996
  5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables adenosylcobinamide-GDP ribazoletransferase activity EXP
Inferred from Experiment
more info
 PubMed 
enables adenosylcobinamide-GDP ribazoletransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables cobalamin 5'-phosphate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cobalamin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cobalamin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cobalamin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
cobalamin 5'-phosphate synthase
NP_416496.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2064479..2065222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416496.1 cobalamin 5'-phosphate synthase

    See identical proteins and their annotated locations for NP_416496.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376WWL8, A0A7A7AY87, A0A8T6PUF3
    Conserved Domains (1) summary
    TIGR00317
    Location:1 → 246
    cobS; cobalamin 5'-phosphate synthase/cobalamin synthase
Nucleotide Protein
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