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cobT nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946517, updated on 30-Jul-2025
Official Symbol
cobT
Official Full Name
nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Primary source
ECOCYC:EG12151
Locus tag
b1991
See related
ASAP:ABE-0006611
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1986
Summary
Escherichia coli K-12, as well as natural isolates, can synthesize cobalamin only when supplied with the intermediate cobinamide . cobT encodes a predicted dimethylbenzimidazole phosphoribosyltransferase. [More information is available at EcoCyc: EG12151].
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Sequence:
NC_000913.3 (2063388..2064467, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Asn Neighboring gene L,D-transpeptidase LdtA Neighboring gene cobalamin 5'-phosphate synthase Neighboring gene cobinamide-P guanylyltransferase/cobinamide kinase Neighboring gene pseudo

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Evolution of coenzyme B12 synthesis among enteric bacteria: evidence for loss and reacquisition of a multigene complex. Lawrence JG, et al. Genetics, 1996 Jan. PMID 8770581, Free PMC Article
  2. A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map. Itoh T, et al. DNA Res, 1996 Dec 31. PMID 9097040
  3. The cobalamin (coenzyme B12) biosynthetic genes of Escherichia coli. Lawrence JG, et al. J Bacteriol, 1995 Nov. PMID 7592411, Free PMC Article
  4. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article
  5. The complete genome sequence of Escherichia coli K-12. Blattner FR, et al. Science, 1997 Sep 5. PMID 9278503

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity EXP
Inferred from Experiment
more info
 PubMed 
enables nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cobalamin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cobalamin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cobalamin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Preferred Names
nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
NP_416495.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2063388..2064467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416495.1 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

    See identical proteins and their annotated locations for NP_416495.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3L9HVU9
    Conserved Domains (1) summary
    PRK00105
    Location:14 → 348
    cobT; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Reviewed
Nucleotide Protein
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