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hisF imidazole glycerol phosphate synthase subunit HisF [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946516, updated on 6-May-2021

Summary

Gene symbol
hisF
Gene description
imidazole glycerol phosphate synthase subunit HisF
Primary source
ASAP:ABE-0006727
Locus tag
b2025
See related
ECOCYC:EG10448
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2020
Summary
N-terminus of purified HisF was sequenced by Klem and Davisson (1993), and the fMet is not clipped. [More information is available at EcoGene: EG10448]. Imidazole glycerol phosphate synthase (HisFH) is a heterodimer that carries out the fifth step in histidine biosynthesis, as well as generating aminoimidazole carboxamide ribonucleotide, an intermediate in purine nucleotide biosynthesis. [More information is available at EcoCyc: EG10448].
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Genomic context

Sequence:
NC_000913.3 (2095844..2096620)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene histidinal/histidinol dehydrogenase Neighboring gene histidinol-phosphate aminotransferase Neighboring gene imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase Neighboring gene imidazole glycerol phosphate synthase subunit HisH Neighboring gene 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase Neighboring gene putative bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase Neighboring gene regulator of length of O-antigen component of lipopolysaccharide chains Neighboring gene UDP-glucose 6-dehydrogenase

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables imidazoleglycerol-phosphate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables imidazoleglycerol-phosphate synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables imidazoleglycerol-phosphate synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of imidazoleglycerol-phosphate synthase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
imidazole glycerol phosphate synthase subunit HisF
NP_416529.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2095844..2096620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416529.1 imidazole glycerol phosphate synthase subunit HisF [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416529.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P60664
    Conserved Domains (1) summary
    PRK02083
    Location:1257
    PRK02083; imidazole glycerol phosphate synthase subunit HisF; Provisional
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