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hisI [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946515, updated on 11-Sep-2024

Summary

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Official Symbol
hisI
Primary source
ECOCYC:EG10451
Locus tag
b2026
See related
ASAP:ABE-0006729
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2021; hisE; hisIE
Summary
After four hours of Zn(II) stress, HisJ protein levels decreased (Easton, 2006). [More information is available at EcoGene: EG10451]. HisI is predicted to be a bifunctional enzyme carrying out the second and third steps in the biosynthesis of histidine. [More information is available at EcoCyc: EG10451].
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Genomic context

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Sequence:
NC_000913.3 (2096614..2097225)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene histidinol-phosphate aminotransferase Neighboring gene imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase Neighboring gene imidazole glycerol phosphate synthase subunit HisH Neighboring gene 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase Neighboring gene imidazole glycerol phosphate synthase subunit HisF Neighboring gene O-antigen co-polymerase Neighboring gene UDP-glucose 6-dehydrogenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PHOSPHORIBOSYLADENOSINE MONOPHOSPHATE, AN INTERMEDIATE IN HISTIDINE BIOSYNTHESIS. SMITH DW, et al. J Biol Chem, 1965 Jul. PMID 14342333
  2. Powerful mutator activity of the polA1 mutation within the histidine region of Escherichia coli K-12. Savić DJ, et al. J Bacteriol, 1982 Mar. PMID 7037745, Free PMC Article
  3. Conservation of primary structure in the hisI gene of the archaebacterium, Methanococcus vannielii, the eubacterium Escherichia coli, and the eucaryote Saccharomyces cerevisiae. Beckler GS, et al. Mol Gen Genet, 1986 Jul. PMID 3018439
  4. Isolation and characterization of a histidine biosynthetic gene in Arabidopsis encoding a polypeptide with two separate domains for phosphoribosyl-ATP pyrophosphohydrolase and phosphoribosyl-AMP cyclohydrolase. Fujimori K, et al. Plant Physiol, 1998 Sep. PMID 9733547, Free PMC Article
  5. Nucleotide sequence of the Escherichia coli hisD gene and of the Escherichia coli and Salmonella typhimurium hisIE region. Chiariotti L, et al. Mol Gen Genet, 1986 Jun. PMID 3018428

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosyl-AMP cyclohydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosyl-AMP cyclohydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables phosphoribosyl-ATP diphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosyl-ATP diphosphatase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-histidine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-histidine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
putative bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase
NP_416530.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2096614..2097225
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416530.1 putative bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416530.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9GDT4
    Conserved Domains (1) summary
    PRK02759
    Location:3 → 202
    PRK02759; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE
Nucleotide Protein
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