U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

sxy transcriptional coactivator for CRP [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946504, updated on 10-Feb-2026
Official Symbol
sxy
Official Full Name
transcriptional coactivator for CRP
Primary source
ECOCYC:G6494
Locus tag
b0959
See related
ASAP:ABE-0003249
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0950; yccR
Summary
CRP-S are specialized CRP-dependent promoters that also require the Sxy gene product for expression (Cameron, 2006). [More information is available at EcoGene: EG13720]. Sxy is required for transcription from a subset of CRP-activated promoters. [More information is available at EcoCyc: G6494].
Try the new Gene page
Try the new Transcripts and proteins table
Sequence:
NC_000913.3 (1021138..1021767)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene outer membrane protein A Neighboring gene cell division inhibitor SulA Neighboring gene putative transporter YccS Neighboring gene PF03733 family inner membrane protein YccF Neighboring gene DNA helicase IV

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. sxy-1, a Haemophilus influenzae mutation causing greatly enhanced spontaneous competence. Redfield RJ. J Bacteriol, 1991 Sep. PMID 1653215, Free PMC Article
  2. CRP-dependent positive autoregulation and proteolytic degradation regulate competence activator Sxy of Escherichia coli. Jaskólska M, et al. Mol Microbiol, 2015 Mar. PMID 25491382
  3. Sxy induces a CRP-S regulon in Escherichia coli. Sinha S, et al. J Bacteriol, 2009 Aug. PMID 19502395, Free PMC Article
  4. Non-canonical CRP sites control competence regulons in Escherichia coli and many other gamma-proteobacteria. Cameron AD, et al. Nucleic Acids Res, 2006. PMID 17068078, Free PMC Article
  5. The Haemophilus influenzae sxy-1 mutation is in a newly identified gene essential for competence. Williams PM, et al. J Bacteriol, 1994 Nov. PMID 7961436, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA import into cell involved in transformation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA import into cell involved in transformation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of competence for transformation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of type IV pilus biogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
transcriptional coactivator for CRP

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1021138..1021767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415479.1 transcriptional coactivator for CRP

    See identical proteins and their annotated locations for NP_415479.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5B9ANL3, A0AAN4E264
    Conserved Domains (2) summary
    COG3070
    Location:2 → 121
    TfoX; Transcriptional regulator of competence genes, TfoX/Sxy family [Transcription]
    pfam04994
    Location:115 → 195
    TfoX_C; TfoX C-terminal domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.