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cbl DNA-binding transcriptional activator Cbl [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946502, updated on 4-Feb-2026
Official Symbol
cbl
Official Full Name
DNA-binding transcriptional activator Cbl
Primary source
ECOCYC:G7071
Locus tag
b1987
See related
ASAP:ABE-0006590
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1982
Summary
Adenosine 5'-phosphosulphate is probably a negative cofactor of Cbl, a sulfur starvation regulator. [More information is available at EcoGene: EG14264]. Cbl is a dual transcriptional regulator of cysteine biosynthesis that activates the transcription of the tauABCD operon. [More information is available at EcoCyc: G7071].
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Sequence:
NC_000913.3 (2059964..2060914, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene FMN/FAD exporter Neighboring gene tRNA-Asn Neighboring gene DNA-binding transcriptional dual regulator Nac Neighboring gene tRNA-Asn

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Crystallization and preliminary crystallographic studies of the cofactor-binding domain of the LysR-type transcriptional regulator Cbl from Escherichia coli. Stec E, et al. Acta Crystallogr D Biol Crystallogr, 2004 Sep. PMID 15333946
  2. Riding the sulfur cycle--metabolism of sulfonates and sulfate esters in gram-negative bacteria. Kertesz MA. FEMS Microbiol Rev, 2000 Apr. PMID 10717312
  3. Observations on the calcium dependence and reversibility of cobalamin transport across the outer membrane of Escherichia coli. Cadieux N, et al. J Biol Chem, 2007 Nov 30. PMID 17908684
  4. Sulfur and nitrogen limitation in Escherichia coli K-12: specific homeostatic responses. Gyaneshwar P, et al. J Bacteriol, 2005 Feb. PMID 15659685, Free PMC Article
  5. Cysteine metabolism-related genes and bacterial resistance to potassium tellurite. Fuentes DE, et al. J Bacteriol, 2007 Dec. PMID 17951385, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in L-cysteine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of sulfur utilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
DNA-binding transcriptional activator Cbl

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2059964..2060914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416492.1 DNA-binding transcriptional activator Cbl

    See identical proteins and their annotated locations for NP_416492.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S7FJT8
    Conserved Domains (1) summary
    PRK12679
    Location:1 → 316
    cbl; HTH-type transcriptional regulator Cbl
Nucleotide Protein
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