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msrP protein-L-methionine sulfoxide reductase catalytic subunit MsrP [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946484, updated on 30-Jul-2025
Official Symbol
msrP
Official Full Name
protein-L-methionine sulfoxide reductase catalytic subunit MsrP
Primary source
ECOCYC:G7059
Locus tag
b1971
See related
ASAP:ABE-0006540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1967; yedY
Summary
YedZY has other in vitro substrates, physiological role unknown; mutant had no growth defect. [More information is available at EcoGene: EG14047]. YedY is a periplasmic molybdoprotein that contains a twin-arginine signal peptide. [More information is available at EcoCyc: G7059].
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Sequence:
NC_000913.3 (2039478..2040482)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene sensor histidine kinase HprS Neighboring gene DNA-binding transcriptional dual regulator HprR Neighboring gene hydroxyisourate hydrolase/transthyretin-related protein Neighboring gene membrane-bound flavocytochrome MsrQ Neighboring gene metal-binding protein ZinT

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Structure of the molybdenum site in YedY, a sulfite oxidase homologue from Escherichia coli. Havelius KG, et al. Inorg Chem, 2011 Feb 7. PMID 21190337
  2. Molybdenum site structure of Escherichia coli YedY, a novel bacterial oxidoreductase. Pushie MJ, et al. Inorg Chem, 2011 Feb 7. PMID 21190336
  3. Evolutionary persistence of the molybdopyranopterin-containing sulfite oxidase protein fold. Workun GJ, et al. Microbiol Mol Biol Rev, 2008 Jun. PMID 18535145, Free PMC Article
  4. Molybdenum cofactor-dependent resistance to N-hydroxylated base analogs in Escherichia coli is independent of MobA function. Kozmin SG, et al. Mutat Res, 2007 Jun 1. PMID 17349664, Free PMC Article
  5. Differential Interactions between Tat-specific redox enzyme peptides and their chaperones. Chan CS, et al. J Bacteriol, 2009 Apr. PMID 19151138, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study investigated the atomic structure of the molybdenum site in YedY by X-ray absorption spectroscopy
    Title: Structure of the molybdenum site in YedY, a sulfite oxidase homologue from Escherichia coli.
  2. The study reports on the structural characterization using X-ray absorption spectroscopy of the molybdenum site of Escherichia coli YedY.
    Title: Molybdenum site structure of Escherichia coli YedY, a novel bacterial oxidoreductase.
  3. N-terminus verified by Edman degradation on mature peptide
    Title: Structural and biochemical identification of a novel bacterial oxidoreductase.
  4. YedY is a sulfite oxidase catalytic subunit with a twin arginine leader sequence for export to the periplasm by the Tat translocation system.
    Title: Characterization of an Escherichia coli sulfite oxidase homologue reveals the role of a conserved active site cysteine in assembly and function.
  5. YedY and its many orthologues may represent a new type of membrane-associated bacterial reductase.
    Title: Structural and biochemical identification of a novel bacterial oxidoreductase.
Submit: New GeneRIF Correction

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molybdopterin cofactor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molybdopterin cofactor binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on a heme group of donors IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on a sulfur group of donors IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein repair IEA
Inferred from Electronic Annotation
more info
  
involved_in response to hypochlorite IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
protein-L-methionine sulfoxide reductase catalytic subunit MsrP

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2039478..2040482
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416480.1 protein-L-methionine sulfoxide reductase catalytic subunit MsrP

    See identical proteins and their annotated locations for NP_416480.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A376K4H8
    Conserved Domains (1) summary
    PRK05363
    Location:1 → 334
    PRK05363; protein-methionine-sulfoxide reductase catalytic subunit MsrP
Nucleotide Protein
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